Simultaneous Detection and Evaluation of Four Subsets of CD4+ T Lymphocyte in Lesions and Peripheral Blood in Endometriosis

Masashi Takamura, Kaori Koga, Gentaro Izumi, Tetsuya Hirata, Miyuki Harada, Yasushi Hirota, Osamu Hiraike, Tomoyuki Fujii, Yutaka Osuga
American journal of reproductive immunology (New York, N.Y. : 1989) · 2015 · vol. 74(6) , pp. 480–486 · doi:10.1111/aji.12426 · PMID:26387982 · W1895445585
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This study found altered proportions of Th1 and Th17 T lymphocytes in endometriosis lesions and higher Th1 proportions in the peripheral blood of women with endometriosis.

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Abstract

PROBLEM: The proportion of CD4+ T lymphocytes, Th1, Th2, Th17, and regulatory T cells in endometriosis lesions and peripheral blood are not known. METHOD OF STUDY: Lymphocytes were isolated from endometriosis lesions (n = 10) and endometrium (n = 10). Lymphocytes in peripheral blood were isolated from patients with and without endometriosis (n = 10, 10). The CD4+ T-lymphocyte profile was analyzed by flow cytometry. RESULTS: The proportion of Th1 lymphocytes was significantly lower in endometriosis tissue (59.64 ± 9.2%) in comparison with endometrial tissue (79.07 ± 8.97%), whereas the Th17 lymphocyte fraction was significantly higher in endometriosis tissue (6.66 ± 2.53%) in comparison with endometrial tissue (2.27 ± 1.51%). Analysis of peripheral blood indicated that the Th1 proportion was significantly higher in women with endometriosis (10.25 ± 2.82%) in comparison with controls (6.96 ± 4.13%). CONCLUSION: The CD4+ T-lymphocyte profile in lesions and peripheral blood is altered in women with endometriosis. These findings may help better understanding of T-lymphocyte involvement in the pathophysiology of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

CD4-Positive T-Lymphocytes Endometriosis T-Lymphocyte Subsets Adult CD4-Positive T-Lymphocytes Cell Separation Cytokines Cytokines Endometriosis Female Flow Cytometry Humans Middle Aged T-Lymphocyte Subsets

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