The biological role of Treg cells in ectopic endometrium homeostasis.
review
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⤵ 14 in-corpus citations
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This review discusses the physiological alterations of Treg cell infiltration into the endometrium and their role in miscarriage, ectopic pregnancy, and the survival of endometriosis foci.
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Abstract
Although retrograde menstruation is observed in up to 90% of women, endometriosis actually develops in only 15% of women. There is considerable evidence in the literature that ectopic endometrial cells are able to evade immune surveillance and that the immune response in the microenvironment of ectopic lesions is limited. Endometriosis develops when a deficiency in the local immune response has been generated, and progression of the disease is related to the intensity of this process. Over the last couple of decades it has been well known that T regulatory lymphocytes (Tregs) play a crucial role in controlling a variety of physiological and pathological immune responses. In this review we have focused on the physiological alteration of Treg cell infiltration into the endometrium during the reproductive processes of women. We discuss how a disturbance in Treg cell expansion is involved in generating such pathological processes as miscarriage and ectopic pregnancy development. We hypothesize about the role Treg cells might play in the survival of endometriosis foci in ectopic localization and in the evasion of such lesions from host immune surveillance.
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Cited by (14)
- Disrupted Tuzzerella abundance and impaired l-glutamine levels induce Treg accumulation in ovarian endometriosis: a comprehensive multi-omics analysis 2024
- Unraveling the microbial puzzle: exploring the intricate role of gut microbiota in endometriosis pathogenesis 2024
- MicroRNAs in Endometriosis: Insights into Inflammation and Progesterone Resistance 2023
- Peritoneal immune microenvironment of endometriosis: Role and therapeutic perspectives 2023
- Epigenetic regulation and T-cell responses in endometriosis – something other than autoimmunity 2022
- Circulating CD200 is increased in the secretory phase of women with endometriosis as is endometrial mRNA, and endometrial stromal cell CD200R1 is increased in spite of reduced mRNA 2022
- Role of Th1, Th2, Th17, and regulatory T cells in endometriosis 2021
- Endometriosis and ovarian cancer - what they have in common? 2020
- T-cadherin deficiency promotes endometriosis progression through the PI3K/AKT/mTOR signaling pathway 2020
- Differential Levels of Regulatory T Cells and T-Helper-17 Cells in Women With Early and Advanced Endometriosis 2019
- Association between FOXP3+ regulatory T-cells and occurrence of peritoneal lesions in women with ovarian endometrioma and dermoid cysts 2019
- Endometriosis-associated Ovarian Cancers 2017
- “What do we know about regulatory T cells and endometriosis? A systematic review” 2017
- Simultaneous Detection and Evaluation of Four Subsets of CD4+ T Lymphocyte in Lesions and Peripheral Blood in Endometriosis 2015
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- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:18:29.016410+00:00
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