The biological role of Treg cells in ectopic endometrium homeostasis

Pawel Basta, Paweł Basta, Basta P, Koper K, Krzysztof Koper, Wojciech Kaźmierczak, Kazmierczak W, Wojciech Kazmierczak, Michal Wisniewski, Wisniewski M, Marcin Wiśniewski, Makarewicz A, Adrianna Makarewicz, Magdalena Dutsch-Wicherek, Magdalena Dutsch‐Wicherek, Zbigniew Kojs, Kojs Z, Popiela TJ, Tadeusz J Popiela, Tadeusz Popiela, Slusarz R, Robert Slusarz, Robert Ślusarz, Mariusz Dubiel, Dubiel M, Łukasz Wicherek, Lukasz Wicherek
Histology and histopathology · 2014 · vol. 29(10) , pp. 1217–33 · doi:10.14670/hh-29.1217 · PMID:24831778 · W2209889392
Review OA: green CC0 ⤵ 14 in-corpus citations
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This review discusses the physiological alterations of Treg cell infiltration into the endometrium and their role in miscarriage, ectopic pregnancy, and the survival of endometriosis foci.

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Abstract

Although retrograde menstruation is observed in up to 90% of women, endometriosis actually develops in only 15% of women. There is considerable evidence in the literature that ectopic endometrial cells are able to evade immune surveillance and that the immune response in the microenvironment of ectopic lesions is limited. Endometriosis develops when a deficiency in the local immune response has been generated, and progression of the disease is related to the intensity of this process. Over the last couple of decades it has been well known that T regulatory lymphocytes (Tregs) play a crucial role in controlling a variety of physiological and pathological immune responses. In this review we have focused on the physiological alteration of Treg cell infiltration into the endometrium during the reproductive processes of women. We discuss how a disturbance in Treg cell expansion is involved in generating such pathological processes as miscarriage and ectopic pregnancy development. We hypothesize about the role Treg cells might play in the survival of endometriosis foci in ectopic localization and in the evasion of such lesions from host immune surveillance.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Homeostasis T-Lymphocytes, Regulatory Animals Animals Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female Homeostasis Homeostasis Humans Humans T-Lymphocytes, Regulatory T-Lymphocytes, Regulatory

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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