Endometriosis-associated Ovarian Cancers

Michael S. Anglesio, Paul J. Yong
Clinical Obstetrics and Gynecology · 2017 · vol. 60(4) , pp. 711–727 · doi:10.1097/grf.0000000000000320 · PMID:28990985 · W2763520660
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This review explores the relationship between endometriosis and ovarian carcinomas, highlighting premalignant lesions, their cancerous counterparts, and the role of mutations and the microenvironment in malignant transformation.

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Abstract

Endometriosis-associated cancers include clear cell and endometrioid ovarian carcinoma. A history of endometriosis has long been considered to be a risk factor for later development of these malignancies; however, recent molecular genetic evidence has provided unequivocal evidence that these lesions are in fact the precursors for endometriosis-associated cancers. Herein, we will explore the relationship between endometriosis and ovarian carcinomas, similarities between the premalignant lesions and their cancerous counterparts, and the potential role of mutations and the ovarian microenvironment that may contribute to malignant transformation.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Carcinoma, Endometrioid Endometriosis Neoplasms, Glandular and Epithelial Ovarian Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Ovarian Epithelial Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans Mutation Neoplasms, Glandular and Epithelial Neoplasms, Glandular and Epithelial

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (50)

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License: CC0 · commercial use OK