Endometrial cancer with concomitant endometriosis is highly associated with ovarian endometrioid carcinoma: a retrospective cohort study

Aya Ishizaka, Ayumi Taguchi, Tetsushi Tsuruga, Marie Maruyama, Akira Kawata, Yuichiro Miyamoto, Michihiro Tanikawa, Masako Ikemura, Kenbun Sone, Mayuyo Mori, Kaori Koga, Tetsuo Ushiku, Katsutoshi Oda, Yutaka Osuga
BMC women's health · 2022 · vol. 22(1) , pp. 332 · doi:10.1186/s12905-022-01917-5 · PMID:35932070 · PMC9354371 · W4289884071
article OA: gold CC0 ⤵ 8 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

Endometrial cancer patients with endometriosis show a high incidence of simultaneous ovarian endometrioid carcinoma, suggesting a shared origin.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This retrospective cohort study reviewed 376 surgically treated stage I–III endometrial cancer patients (2007–2015) and compared clinicopathological features between those with and without pathologically detected endometriosis, focusing particularly on simultaneous endometrial and ovarian cancer (SEOC). Patients with endometriosis were younger and more often had endometrioid endometrial tumors of grade 1/2, and progression-free survival and overall survival did not differ by endometriosis status; the study’s explicit limitation is its retrospective, single-institution design. The incidence of SEOCs was significantly higher in patients with endometriosis (12/51, 24%) than without (p < 0.0001), and all ovarian cancers occurring in the endometriosis group were endometrioid carcinomas; even among patients without endometriosis, endometrioid was the most common SEOC histologic type. This paper is centrally about endometriosis—specifically the association between concomitant endometriosis in endometrial cancer patients and a higher probability and endometrioid predominance of ovarian endometrioid carcinoma as simultaneous disease (SEOC).

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Abstract

BACKGROUND: Endometriosis is assumed to be involved in ovarian cancer development, which is called endometriosis-associated ovarian cancer (EAOC). Uterine endometrial cells may be the cell of origin of EAOC. Accumulated carcinogenic changes in the uterine endometrial cells may increase the risk of developing EAOC. To further understand the pathogenesis of EAOCs, we focused on the clinicopathological characteristics of EAOCs in endometrial cancer patients with concomitant endometriosis. METHODS: We retrospectively reviewed 376 patients who were surgically treated for stage I-III endometrial cancer. Clinicopathological characteristics were compared between patients with and without endometriosis. Furthermore, the incidence of simultaneous endometrial and ovarian cancer (SEOC) and the histological characteristics of SEOC were compared between the two groups. RESULTS: Among 376 patients with endometrial cancer, 51 had concomitant endometriosis. Patients with endometriosis were significantly younger and more frequently had endometrioid G1/G2 tumors than those without endometriosis. The incidence of SEOCs was significantly higher in endometrial cancer patients with endometriosis than those without it (p < 0.0001); notably, 12 of 51 endometrial cancer patients with endometriosis (24%) had SEOCs. All of the ovarian cancers in endometrial cancer patients with endometriosis were endometrioid carcinomas. Moreover, even in those without endometriosis, endometrioid carcinoma was the most common histological type of SEOC. CONCLUSION: We revealed that endometrial cancer patients with endometriosis had a high probability of SEOC and that endometrioid carcinoma was the most common histological subtype of SEOC regardless of the presence of endometriosis. For patients with endometrial cancer and endometriosis, careful examination of ovarian endometriotic lesions may be important to detect EAOCs.

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Condition tags

endometriosis

MeSH descriptors

Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms

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