Ovarian clear cell carcinoma—bad endometriosis or bad endometrium?

Ioannis Gounaris, D Stephen Charnock-Jones, D. Stephen Charnock‐Jones, James D Brenton
The Journal of Pathology · 2011 · vol. 225(2) , pp. 157–160 · doi:10.1002/path.2970 · PMID:21898874 · W1978505323
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This paper examines the distinct origins and molecular drivers of ovarian clear cell carcinoma, highlighting PIK3CA mutations in precursor endometriosis and suggesting further investigation into endometrial mutations predisposing to malignancy.

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Abstract

It has become increasingly clear that the four main histological subtypes of epithelial ovarian cancer (EOC), high-grade serous, endometrioid, clear cell and mucinous, are entities with different epidemiologies, clinical presentations, responses to treatment, and ultimate outcomes. In fact, for all intents and purposes, they can be considered different diseases, their only common denominator being that they frequently involve the ovary and pelvic organs. However, clinical practice has not caught up with these insights and the treatment of EOC is that of a single disease entity. In part, this is because we lack detailed knowledge of the molecular mechanisms driving the pathogenesis of each disease, which is vital in order to develop therapeutic approaches against common driver events. In the last few years, mutations in ARID1A and PIK3CA have been described in a substantial fraction of cases of ovarian clear cell carcinoma, yet the paper by Yamamoto et al in this issue of The Journal of Pathology reveals that PIK3CA mutations can be detected in precursor endometriosis tissues. These and other recent observations underscore the importance of investigating whether mutations in the eutopic endometrium actually predispose to endometriosis and eventually to malignancy.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Endometriosis Mutation Ovarian Neoplasms Phosphatidylinositol 3-Kinases Precancerous Conditions Adenocarcinoma, Clear Cell Class I Phosphatidylinositol 3-Kinases Endometriosis Female Humans Ovarian Neoplasms Phosphatidylinositol 3-Kinases Precancerous Conditions

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (20)

Cited by (21)

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