Molecular Pathogenesis of Ovarian Clear Cell Carcinoma

Ioannis Gounaris, James D Brenton
Future oncology (London, England) · 2015 · vol. 11(9) , pp. 1389–1405 · doi:10.2217/fon.15.45 · PMID:25952785 · W1890769242
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Ovarian clear cell carcinoma, linked to endometriosis and glycogen, is driven by ARID1A mutations and HNF1B overexpression, with ongoing research into glycogen's role and the development of better disease models.

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Abstract

Ovarian clear cell carcinoma is a distinct subtype of epithelial ovarian cancer, characterized by an association with endometriosis, glycogen accumulation and resistance to chemotherapy. Key driver events, including ARID1A mutations and HNF1B overexpression, have been recently identified and their functional characterization is ongoing. Additionally, the role of glycogen in promoting the malignant phenotype is coming under scrutiny. Appreciation of the notion that ovarian clear cell carcinoma is essentially an ectopic uterine cancer will hopefully lead to improved animal models of the disease, in turn paving the way for effective treatments.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Cell Transformation, Neoplastic Ovarian Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Animals Carcinoma, Ovarian Epithelial Cell Transformation, Neoplastic Disease Models, Animal DNA-Binding Proteins Female Gene Expression Regulation, Neoplastic Humans Mutation Neoplasms, Glandular and Epithelial Neoplasms, Glandular and Epithelial Neoplasms, Glandular and Epithelial Neoplasms, Glandular and Epithelial Nuclear Proteins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (2)

Source provenance

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