Oestrogen up-regulates DNMT1 and leads to the hypermethylation of RUNX3 in the malignant transformation of ovarian endometriosis

Danbo Wang, Cuishan Guo, Yan Li, Ming-Yi Zhou, Mingyi Zhou, Huimin Wang, Jing Liu, Peng Chen
Reproductive biomedicine online · 2021 · vol. 44(1) , pp. 27–37 · doi:10.1016/j.rbmo.2021.06.030 · PMID:34799276 · W3186115202
article OA: closed CC0 ⤵ 15 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This research investigated how estrogen affects DNA methylation in ovarian endometriosis and found that estrogen up-regulates DNMT1, leading to the hypermethylation of RUNX3 during malignant transformation.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Ovarian Neoplasms Ovarian Neoplasms Cell Transformation, Neoplastic Cell Transformation, Neoplastic Cell Transformation, Neoplastic Cell Transformation, Neoplastic Core Binding Factor Alpha 3 Subunit Core Binding Factor Alpha 3 Subunit Core Binding Factor Alpha 3 Subunit Endometrium Endometrium Estradiol Estradiol Estradiol Estrogens Estrogens Female Humans

Citation neighborhood

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References (50)

Cited by (15)

Source provenance

europepmc
last seen: 2026-06-18T06:15:08.409253+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:24:08.918168+00:00
License: CC0 · commercial use OK