Increased IL-25 levels in the peritoneal fluid of patients with endometriosis

Bungum HF, Helle Folge Bungum, Uffe Nygaard, Christian Vestergaard, Pia M. Martensen, Ulla Breth Knudsen
Journal of Reproductive Immunology · 2016 · vol. 114 , pp. 6–9 · doi:10.1016/j.jri.2016.01.003 · PMID:26852387 · W2315370995
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This paper investigated the levels of IL-25 in peritoneal fluid and found them to be increased in patients diagnosed with endometriosis.

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Abstract

Previous studies have indicated a higher prevalence of allergic disease among women with endometriosis. It is already well established that type 1 allergies develop in a Th2 cytokine environment. Recent studies have shown, however, that IL-25 induces a Th2 development of naive T lymphocytes and is central in the Th2 response. The aim of this case-control study was to investigate the presence of IL-25 in the peritoneal fluid of women suffering from endometriosis. PF was obtained both from women undergoing laparoscopic surgery due to endometriosis (25 cases) and from women wanting sterilisation (19 controls). IL-25 levels were then investigated by ELISA. Women with endometriosis showed significantly higher levels of IL-25 in their PF (p=0.019) compared to controls. IL-25 levels did not correlate with the stage of endometriosis. Both Th2-cells and mast cells express IL-25, which could favor the development of allergies by perpetuating a hypersensitivity reaction. Further, IL-25 may also hold a role as a diagnostic tool.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Interleukin-17 Mast Cells Th2 Cells Adult Ascitic Fluid Ascitic Fluid Case-Control Studies Endometriosis Endometriosis Female Humans Interleukin-17 Interleukin-17 Laparoscopy Mast Cells Mast Cells Th2 Cells Th2 Cells

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (25)

Cited by (15)

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