Increased IL-25 levels in the peritoneal fluid of patients with endometriosis

Bungum HF, Helle Folge Bungum, Uffe Nygaard, Christian Vestergaard, Pia M. Martensen, Ulla Breth Knudsen
Journal of Reproductive Immunology · 2016 · vol. 114 , pp. 6–9 · doi:10.1016/j.jri.2016.01.003 · PMID:26852387 · W2315370995
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This paper investigated the levels of IL-25 in peritoneal fluid and found them to be increased in patients diagnosed with endometriosis.

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Abstract

Previous studies have indicated a higher prevalence of allergic disease among women with endometriosis. It is already well established that type 1 allergies develop in a Th2 cytokine environment. Recent studies have shown, however, that IL-25 induces a Th2 development of naive T lymphocytes and is central in the Th2 response. The aim of this case-control study was to investigate the presence of IL-25 in the peritoneal fluid of women suffering from endometriosis. PF was obtained both from women undergoing laparoscopic surgery due to endometriosis (25 cases) and from women wanting sterilisation (19 controls). IL-25 levels were then investigated by ELISA. Women with endometriosis showed significantly higher levels of IL-25 in their PF (p=0.019) compared to controls. IL-25 levels did not correlate with the stage of endometriosis. Both Th2-cells and mast cells express IL-25, which could favor the development of allergies by perpetuating a hypersensitivity reaction. Further, IL-25 may also hold a role as a diagnostic tool.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Interleukin-17 Mast Cells Th2 Cells Adult Adult Ascitic Fluid Ascitic Fluid Ascitic Fluid Case-Control Studies Case-Control Studies Endometriosis Endometriosis Endometriosis Female Female Humans Humans Interleukin-17

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (25)

Cited by (15)

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