Interleukin-17F increases the secretion of interleukin-8 and the expression of cyclooxygenase 2 in endometriosis

Tetsuya Hirata, Osuga Y, Yutaka Osuga, Takamura M, Masashi Takamura, Saito A, Ako Saito, Hasegawa A, Akiko Hasegawa, Kaori Koga, Osamu Yoshino, Yoshino O, Yasushi Hirota, Miyuki Harada, Taketani Y, Yuji Taketani
Fertility and sterility · 2011 · vol. 96(1) , pp. 113–117 · doi:10.1016/j.fertnstert.2011.04.060 · PMID:21601196 · W2012212752
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Interleukin-17F was found to increase interleukin-8 secretion and cyclooxygenase 2 expression in endometriosis.

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Abstract

ObjectiveTo examine the effects of interleukin (IL)-17F on the secretion of IL-8 and the gene expression of cyclooxygenase 2 (COX2) in endometriotic stromal cells.DesignIn vitro experimental study using human samples.SettingUniversity hospital.Patient(s)Endometriotic tissues were obtained from women with ovarian endometriomas undergoing laparoscopic surgery.Intervention(s)Endometriotic stromal cells (ESCs) were cultured with IL-17F.Main outcome measure(s)Concentrations of IL-8 were measured by a specific ELISA, and messenger RNA levels of IL-8 and COX2 were measured by real-time reverse transcription-polymerase chain reaction (PCR).Result(s)IL-17F increased the secretion of IL-8 from ESCs, and the effect was inhibited by antibodies for IL-17 receptor A and IL-17 receptor C. Tumor necrosis factor α (TNF-α) synergistically enhanced IL-17F-induced increase in IL-8 secretion from ESCs. The IL-17F increased the gene expression of IL-8 and COX2 in ESCs.Conclusion(s)These findings suggest that IL-17F may stimulate the development of endometriosis by up-regulation of IL-8 and COX2.

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Condition tags

endometriosis

MeSH descriptors

Cyclooxygenase 2 Endometriosis Gene Expression Regulation, Enzymologic Interleukin-17 Interleukin-8 Cells, Cultured Cyclooxygenase 2 Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Humans Interleukin-17 Interleukin-8

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