Cyclooxygenase-2 overexpression in ovarian endometriomas is associated with higher risk of recurrence

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Ovarian endometriomas with higher cyclooxygenase-2 expression were associated with an increased risk of recurrence.

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Abstract

Cyclooxegenase-2 expression was evaluated by immunohistochemistry in endometrioma tissue samples taken from 109 patients, of whom 53 had recurrence by 30 months after surgery and 56 did not. Cyclooxegenase-2 overexpression, along with previous medical treatment of endometriosis and the presence of adhesion, is predictive of recurrence of ovarian endometrioma within 30 months after surgery, with a resultant sensitivity of 72.5% and a specificity of 72.4%, suggesting that there are intrinsic and identifiable biomarkers that confer recurrence risk.

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Condition tags

endometriosis

MeSH descriptors

Cyclooxygenase 2 Endometriosis Endometriosis Ovarian Diseases Ovarian Diseases Adult Biomarkers Biomarkers Case-Control Studies Cyclooxygenase 2 Endometriosis Endometriosis Female Gene Expression Regulation, Enzymologic Humans Middle Aged Ovarian Diseases Ovarian Diseases Predictive Value of Tests Recurrence

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