Regulation of endometrial stromal cell matrix metalloproteinase activity and invasiveness by interleukin-8

Naciye Mülayim, Mulayim N, Naciye Mulayim, Asim Savlu, Savlu A, Ozlem Guzeloglu‐Kayisli, Guzeloglu-Kayisli O, Ozlem Guzeloglu-Kayisli, Umit A. Kayisli, Kayisli UA, Aydın Arıcı, Aydin Arici, Arici A
Fertility and sterility · 2004 · vol. 81 , pp. 904–911 · doi:10.1016/j.fertnstert.2003.11.015 · PMID:15019828 · W2007059239
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Interleukin-8 influences endometrial stromal cell matrix metalloproteinase activity and invasiveness.

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Abstract

ObjectiveTo evaluate the effect of interleukin-8 (IL-8) on endometrial stromal cell metalloproteinase (MMP) activity and invasiveness.DesignExperimental laboratory study.SettingUniversity medical center.Patient(s)Reproductive age women without endometriosis.Intervention(s)Endometrial stromal cells were grown in culture and treated with recombinant IL-8 (0.0001-10 ng/mL) for 24 to 48 hours. Supernatants were collected for soluble assay of collagenase activity and gelatin zymography. Endometrial stromal cells were plated on 8-microm pore membranes coated with Matrigel or human simple matrix and treated with IL-8 for 48 hours.Main outcome measure(s)Collagenase activity and MMP2 and 9 activity of control vs. IL-8 treated endometrial cells, and number of endometrial cells that invade through Matrigel or human simple matrix.Result(s)Collagenase activity in cells treated with IL-8 (1-10 ng/mL) was higher than in control cells. On gelatin zymograms, MMP2 and MMP9 activity of endometrial stromal cells was stimulated by IL-8 treatment (1-10 ng/mL). The number of cells that invaded the Matrigel or human simple matrix was 1.7-fold higher in the group treated with 10 ng/mL of IL-8 compared with the control group.Conclusion(s)IL-8 increases MMP activity and invasive capability of endometrial stromal cells in culture; IL-8 may be involved in the pathogenesis of endometriosis and menstrual physiology.

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MeSH descriptors

Endometrium Interleukin-8 Matrix Metalloproteinase 9 Stromal Cells Adult Biocompatible Materials Cell Movement Cell Movement Cells, Cultured Collagen Collagenases Collagenases Collagenases Drug Combinations Endometrium Endometrium Endometrium Endometrium Female Humans

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