CONTENTS OF CHEMOKINES AND CYTOKINES IN PERITONEAL FLUID FROM THE PATIENTS WITH ENDOMETRIOSIS OF VARIOUS SEVERITY

Д. И. Соколов, P. G. Kondratjeva, M. I. Jarmolinskaja, N. L. Kramareva, A. V. Seljutin, V. V. Rulev, Dariko A. Niauri, S. А. Selkov
In: Medical Immunology (Russia) · 2014 · vol. 9(1) , pp. 85 · doi:10.15789/1563-0625-2007-1-85-90 · W1929046523
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Concentrations of RANTES, IP-10, IL-8, MCP-1, MIG, and IL-6 in peritoneal fluid were higher in endometriosis patients, with some correlating to disease severity, while IL-10 was undetectable.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The paper studied the contents of chemokines and cytokines in peritoneal fluid collected from patients with external genital endometriosis of varying severity, using immunological measurements to compare mediator profiles across disease grades. The key finding was that peritoneal fluid levels of specific chemokines/cytokines differed according to endometriosis severity, indicating an association between local inflammatory signaling intensity and disease extent. A major caveat explicitly noted in the presented material is the limited scope of analysis to peritoneal fluid mediator content without further mechanistic confirmation. This paper is centrally about endometriosis — it quantifies chemokine and cytokine contents in peritoneal fluid across endometriosis severity levels.

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Abstract

Endometriosis is a disease accompanied by development of heterotopic endometrial foci at the peritoneum, proliferation of endothelial cells, and inflammatory reaction. Aiming to specify the dynamics of inflammatory process in endometriosis of different severity, as well as significance of chemokines and cytokines in angiogenesis and inflammation, we determined concentrations of RANTES, IL-8, IP-10, MIG, MCP-1 chemokines, as well as IL-4, IL-6 and IL-10 cytokines in peritoneal fluid from patients by endometriosis. Forty women at reproductive age with an endometriosis have been observed. Among them, endometriosis grade I-II was registered in 20 cases, whereas grade III-IV has been confirmed in 20 women. Twenty-two women without evidence of endometriosis referred to diagnostic laparoscopy for pregnancy planning, comprised a control group. Diagnosis of endometriosis was based upon endoscopic findings and results of histological research. Severity grade of endometriosis was estimated according to R-AFS classification. Sampling of peritoneal fluid was carried out when performing surgical laparoscopies. Concentrations of chemokines and cytokines were determined by flow cytometry techniques, using BD Cytometric Bead Array test kits and FACStrack flow cytometer. The amounts of RANTES in peritoneal fluid were higher in grade I-II endometriosis, in comparison with grade III-IV endometriosis and control samples. Concentrations of IP-10, IL-8, МСР-1, MIG, IL-6, and IL-4 were higher than in control group and correlated with severity of the disease. IL-10 was not detectable in peritoneal fluid of the patients with endometriosis. These results suggest a significant role of the mentioned cytokines and chemokines that may promote invasion of endometrial cells, growth of heterotopic endometrioid locuses, development of vascular bed and induction of inflammatory processes, in development and progression of endometriosis.

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endometriosis

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