CONTENTS OF CHEMOKINES AND CYTOKINES IN PERITONEAL FLUID FROM THE PATIENTS WITH ENDOMETRIOSIS OF VARIOUS SEVERITY

Д. И. Соколов, P. G. Kondratjeva, M. I. Jarmolinskaja, N. L. Kramareva, A. V. Seljutin, V. V. Rulev, Dariko A. Niauri, S. А. Selkov
In: Medical Immunology (Russia) · 2014 · vol. 9(1) , pp. 85 · doi:10.15789/1563-0625-2007-1-85-90 · W1929046523
article OA: diamond CC0 ⤵ 5 in-corpus citations
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Concentrations of RANTES, IP-10, IL-8, MCP-1, MIG, and IL-6 in peritoneal fluid were higher in endometriosis patients, with some correlating to disease severity, while IL-10 was undetectable.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

The paper studied the contents of chemokines and cytokines in peritoneal fluid collected from patients with external genital endometriosis of varying severity, using immunological measurements to compare mediator profiles across disease grades. The key finding was that peritoneal fluid levels of specific chemokines/cytokines differed according to endometriosis severity, indicating an association between local inflammatory signaling intensity and disease extent. A major caveat explicitly noted in the presented material is the limited scope of analysis to peritoneal fluid mediator content without further mechanistic confirmation. This paper is centrally about endometriosis — it quantifies chemokine and cytokine contents in peritoneal fluid across endometriosis severity levels.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometriosis is a disease accompanied by development of heterotopic endometrial foci at the peritoneum, proliferation of endothelial cells, and inflammatory reaction. Aiming to specify the dynamics of inflammatory process in endometriosis of different severity, as well as significance of chemokines and cytokines in angiogenesis and inflammation, we determined concentrations of RANTES, IL-8, IP-10, MIG, MCP-1 chemokines, as well as IL-4, IL-6 and IL-10 cytokines in peritoneal fluid from patients by endometriosis. Forty women at reproductive age with an endometriosis have been observed. Among them, endometriosis grade I-II was registered in 20 cases, whereas grade III-IV has been confirmed in 20 women. Twenty-two women without evidence of endometriosis referred to diagnostic laparoscopy for pregnancy planning, comprised a control group. Diagnosis of endometriosis was based upon endoscopic findings and results of histological research. Severity grade of endometriosis was estimated according to R-AFS classification. Sampling of peritoneal fluid was carried out when performing surgical laparoscopies. Concentrations of chemokines and cytokines were determined by flow cytometry techniques, using BD Cytometric Bead Array test kits and FACStrack flow cytometer. The amounts of RANTES in peritoneal fluid were higher in grade I-II endometriosis, in comparison with grade III-IV endometriosis and control samples. Concentrations of IP-10, IL-8, МСР-1, MIG, IL-6, and IL-4 were higher than in control group and correlated with severity of the disease. IL-10 was not detectable in peritoneal fluid of the patients with endometriosis. These results suggest a significant role of the mentioned cytokines and chemokines that may promote invasion of endometrial cells, growth of heterotopic endometrioid locuses, development of vascular bed and induction of inflammatory processes, in development and progression of endometriosis.
Full text 5,966 characters · extracted from oa-doi-fallback · click to expand
СОДЕРЖАНИЕ ХЕМОКИНОВ И ЦИТОКИНОВ В ПЕРИТОНЕАЛЬНОЙ ЖИДКОСТИ БОЛЬНЫХ НАРУЖНЫМ ГЕНИТАЛЬНЫМ ЭНДОМЕТРИОЗОМ РАЗЛИЧНОЙ СТЕПЕНИ ТЯЖЕСТИ https://doi.org/10.15789/1563-0625-2007-1-85-90 Аннотация Об авторах Д. И. СоколовРоссия лаборатория иммунологии Служебный адрес: Менделеевская линия, д.3. Домашний адрес: ул. Крыленко, д. 45, корп. 1, кв. 5. Тел.: (812) 328-98-50. Факс: (812) 323-75-45 П. Г. Кондратьева Россия медицинский факультет, кафедра акушерства и гинекологии М. И. Ярмолинская Россия лаборатория иммунологии Н. Л. Крамарева Россия лаборатория иммунологии А. В. Селютин Россия лаборатория иммунологии В. В. Рулев Россия лаборатория иммунологии Д. А. Ниаури Россия медицинский факультет, кафедра акушерства и гинекологии С. А. Сельков Россия лаборатория иммунологии Список литературы 1. Алиханова З.М. Биологические свойства перитонеальной жидкости в норме и при патологии репродуктивной системы // Акушерство и гинекология. – 1991. – № 9. – С. 3-8. 2. Дамиров М.М., Бакулева Л.П., Шабанов А. М. Клинико-морфологическое сопоставление УЗ-критериев аденомиоза // Акушерство и гинекология. – 1994. – № 2. – С. 40-44. 3. Соколов Д.И., Солодовникова Н.Г., Павлов О.В., Ниаури Д.А. Исследование цитокинового профиля и ангиогенного потенциала перитонеальной жидкости больных с наружным генитальным эндометриозом // Бюл. эксперим. биологии и медицины. – 2005. – Т. 140, № 11. – С. 552-555. 4. Arici A. Local cytokines in endometrial tissue: the role of interleukin-8 in the pathogenesis of endometriosis // Ann. N Y Acad. Sci. – 2002. – Vol. 955. – P. 101-109; discussion 118, P. 396-406. 5. Brenner R.M., Nayak N.R., Slayden O.D., Critchley H.O, Kelly R.W. Premenstrual and menstrual changes in the macaque and human endometrium: relevance to endometriosis // Ann. N Y Acad. Sci. – 2002. – Vol. 955. – P. 60-74; discussion 86-8, P. 396-406. 6. Caballero-Campo P, Dominguez F, Coloma J, Meseguer M, Remohi J, Pellicer A., Simon C. Hormonal and embryonic regulation of chemokines IL-8, MCP-1 and RANTES in the human endometrium during the window of implantation // Mol. Hum. Reprod. – 2002. – Vol. 8. – P. 375-384. 7. Gazvani M.R., Christmas S., Quenby S., Kirwan J, Johnson P.M., Kingsland C.R. Peritoneal fluid concentrations of interleukin-8 in women with endometriosis: relationship to stage of disease // Hum. Reprod. – 1998. – Vol. 13. – P. 1957-1961. 8. Gmyrek G.B., Sozanski R., Jerzak M., Chrobak A., Wickiewicz D., Skupnik A., Sieradzka U., Fortuna W., Gabrys M., Chelmonska-Soyta A. Evaluation of monocyte chemotactic protein-1 levels in peripheral blood of infertile women with endometriosis. // Eur. J. Obstet. Gynecol. Reprod. Biol. – 2005. – Vol. 122, N 2. – P. 199-205. 9. Konno R., Yamada-Okabe H., Fujiwara H., Uchiide I., Shibahara H., Ohwada M., Ihara T., Sugamata M., Suzuki M. Role of immunoreactions and mast cells in pathogenesis of human endometriosis – morphologic study and gene expression analysis // Hum. Cell. – 2003. – Vol. 16, N 3. – P. 141-149. 10. Lasagni L., Francalanci M., Annunziato F., Lazzeri E., Giannini S., Cosmi L., Sagrinati C., Mazzinghi B., Orlando C., Maggi E., Marra F., Romagnani S., Serio M., Romagnani P. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4 // Exp. Med. – 2003. – Vol. 197, N 11. – P. 1537-1549. 11. Lin Y.J., Lai M.D., Lei H.Y., Wing L.Y. Neutrophils and macrophages promote angiogenesis in the early stage of endometriosis in a mouse model // Endocrinology. – 2006. – Vol. 143, N 3. – P. 1278-1286. 12. Mahnke J.L., Dawood M.Y., Huang J.C. Vascular endothelial growth factor and interleukin-6 in peritoneal fluid of women with endometriosis // Fertil. Steril. – 2000. – Vol. 73, N 1. – P. 166-170. 13. McLaren J., Prentice A., Charnock-Jones D.S., Smith S.K. Vascular endothelial growth factor concenration are elevated in peritoneal fluid of women with the endometriosis // Hum. Reprod. – 1996. – Vol. 11. – P. 220-223. 14. Mulayim N., Savlu A., Guzeloglu-Kayisli O., Kayisli U.A., Arici A. Regulation of endometrial stromal cell matrix metalloproteinase activity and invasiveness by interleukin-8 // Fertil. Steril. – 2004. – Vol. 81, N 1. – P. 904-911. 15. Murdoch C., Finn A. Chemokine receptors and their role in inflammation and infectious diseases // Blood. – 2000. – Vol. 95, N 10. – P. 3032- 3043. 16. Nilsson M.B., Langley R.R., Fidler I.J. Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine // Cancer Res. – 2005. – Vol. 65, N 23. – P. 10794-10800. 17. Selam B., Kayisli U.A., Garcia-Velasco J.A., Akbas G.E., Arici A. Regulation of fas ligand expression by IL-8 in human endometrium // J. Clin. Endocrinol Metab. – 2002. – Vol. 87, N 8. – P. 3921-3927. 18. Song M., Karabina S.A., Kavtaradze N., Murphy A.A., Parthasarathy S. Presence of endometrial epithelial cells in the peritoneal cavity and the mesothelial inflammatory response // Fertil. Steril. – 2003. – Vol. 79, N 1. – P. 789-794. 19. Ulukus E.C., Ulukus M., Seval Y., Cinar O., Zheng W., Arici A. Expression of interleukin-8 and monocyte chemotactic protein-1 with adenomyosis // Hum. Reprod. – 2005. – Vol. 20, N 10. – P. 2958-2963. Рецензия Для цитирования: Соколов Д.И., Кондратьева П.Г., Ярмолинская М.И., Крамарева Н.Л., Селютин А.В., Рулев В.В., Ниаури Д.А., Сельков С.А. СОДЕРЖАНИЕ ХЕМОКИНОВ И ЦИТОКИНОВ В ПЕРИТОНЕАЛЬНОЙ ЖИДКОСТИ БОЛЬНЫХ НАРУЖНЫМ ГЕНИТАЛЬНЫМ ЭНДОМЕТРИОЗОМ РАЗЛИЧНОЙ СТЕПЕНИ ТЯЖЕСТИ. Медицинская иммунология. 2007;9(1):85-90. https://doi.org/10.15789/1563-0625-2007-1-85-90 For citation: Sokolov D.I., Kondratjeva P.G., Jarmolinskaja M.I., Kramareva N.L., Seljutin A.V., Rulev V.V., Niauri D.A., Selkov S.A. CONTENTS OF CHEMOKINES AND CYTOKINES IN PERITONEAL FLUID FROM THE PATIENTS WITH ENDOMETRIOSIS OF VARIOUS SEVERITY. Medical Immunology (Russia). 2007;9(1):85-90. (In Russ.) https://doi.org/10.15789/1563-0625-2007-1-85-90 JATS XML

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (13)

Cited by (5)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK