Dariko A. Niauri

BACKGROUND: Although clinical evidence remains inconsistent, growing data suggest that endometriosis is associated with molecular, hormonal, and immune-inflammatory alterations in the eutopic endometrium that may impair endometrial receptiv…

Peritoneal endometriosis and infertility in most of patients (in 80%) are pathogenetically conjugated. Both peritoneal endometriosis and infertility are based in ovarian failure. These women have a low endometrial receptivity for blastocyst…

BACKGROUND: Severe forms of genital endometriosis are known to be associated with infertility and its subsequent treatment failure. Both gonadotropin-releasing hormone analogs (a-GnRH) and dienogest have been suggested as additional hormone…

The aim of this research was to study the frequency of polymorphic variants Val158Met (rs4680) of catechol-O-methyltransferase (COMT) gene in patients with uterine leiomyoma. A polymerase chain reaction was performed to figure out the frequ…

Abstracts Background: Implantation failure of in vitro fertilization (IVF) cycles is recognized as one of key problems in contemporary reproductive medicine. Implantation itself is a multifactorial process and one can hardly expect to find …

Endometriosis is a disease accompanied by development of heterotopic endometrial foci at the peritoneum, proliferation of endothelial cells, and inflammatory reaction. Aiming to specify the dynamics of inflammatory process in endometriosis …

65535 Endometriosis is a pelvic pathological process, when endometriotic lesions require neovascularisation to establish, proliferate and invide inside the peritoneal cavity. We analyzed the role of main angiogenic factors VEGF and bFGF in …

The purpose of this research was the development of endometriosis model on 20 adult female rabbits. The endometriosis modeling with application of various modern surgical procedures was effected. The results was estimated at a laparoscopy a…

The article contains modern data on immune system components role in forming of endometriosis. Immunocompetent cells and some cytokines takepart in mechanisms of endometrioid cells implantation following endometrioid nidus formation. Cytoki…

Intact myometrium specimen, received from 56 women of reproductive age during surgical interventions. There were 30 women with combined hyperplastic processes in the reproductive system organs (uterine myoma, endometrium hyperplasia, adenom…

Secretion of some IL and growth factors (VEGF, IGF-I, TGFbeta) by endometrial tissues and endometrioid heterotopies was studied in vitro in patients with external genital endometriosis of different severity. The production of IL-1beta, IL-2…

The concentrations of proinflammatory cytokines (IL-1beta, IL-6), vascular endothelium growth factor, tumor growth factor-beta, and insulin-like growth factor-1 were measured in the peritoneal fluid of patients with external genital endomet…

The article represents the authors data, gained during studies of systemic and local mechanisms of regulation of immune processes in pathogenesis of external genital endometriosis. Research was carried out into spectrum and production of so…

•·Intact myometrium specimen, received from 56 •women of reproductive age during surgical interventions. There •were 30 women with combined hyperplastic processes in the •reproductive system organs (uterine myoma, endometrium hy•perplasia, …

The exploration of parameters of regional blood flow in aa. uterinae in 22 patients with diffusive form of adenomyosis, in which ovulational menstruational cycle with the lack of lutein phase was registrated and 10 women of control group in…