Catechol-O-methyltransferase polymorphism in women with uterine leiomyoma and adenomyosis

Dariko A. Niauri; Lyailya Kh. Dzhemlikhanova; Alexandr Gzgzyan; Natalia S. Osinovskaya; E.A. Gorovaya; Tatyana E Ivashchenko; Iskender Yu. Sultanov; Antonina Nicolaevna Tkachenko

doi:10.21638/11701/spbu11.2016.310

Catechol-O-methyltransferase polymorphism in women with uterine leiomyoma and adenomyosis

Dariko A. Niauri, Lyailya Kh. Dzhemlikhanova, Alexandr Gzgzyan, Natalia S. Osinovskaya, E.A. Gorovaya, Tatyana E Ivashchenko, Iskender Yu. Sultanov, Antonina Nicolaevna Tkachenko

In: Vestnik of Saint Petersburg University. Medicine · 2016 · vol. 11(3) , pp. 103–110 · doi:10.21638/11701/spbu11.2016.310 · W2765637293

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that the GG genotype of the COMT Val158Met polymorphism is associated with a 2.5-fold increased risk of uterine leiomyoma, but no significant differences were observed between uterine leiomyoma, adenomyosis, and endometrial hyperplasia groups.

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Abstract

The aim of this research was to study the frequency of polymorphic variants Val158Met (rs4680) of catechol-O-methyltransferase (COMT) gene in patients with uterine leiomyoma. A polymerase chain reaction was performed to figure out the frequency of polymorphic alleles of COMT gene in 54 patients with uterine leiomyoma and 103 women from the general population. It is shown that the presence of the genotype g/g of the COMT gene is associated with 2.5 times-increased risk of uterine leiomyoma (RR 2,44, Cl95: 1,168-5,103), whereas the genotype A/A is not associated with the development of leiomyoma. At the same time, a comparative analysis of the genotypes frequencies of the COMT gene polymorphism between groups with different combinations of hyperplastic processes of reproductive system (uterine leiomyoma, adenomyosis, hyperplastic processes of endometrium), showed no statistically significant differences. Refs 26. Tables 3.