Д. И. Соколов

BACKGROUND: Endometriosis plays a leading role in the impairment of fertility. An imbalance of angiogenic factors underlies the pathogenesis of infertility, however, the prognostic value of soluble fms-like tyrosine kinase-1 (sFlt-1) and pl…

External genital endometriosis is a chronic inflammatory disease affecting 10% of women of reproductive age, characterized by neoangiogenesis in endometriotic implants, which is controlled by a variety of factors. Recently, a great deal of …

Background: Endometriosis is a complex condition that impairs women's quality of life and reproductive potential. Its diagnosis remains significant challenge for clinicians. The aim of the study was to investigate cancer-like immune evasion…

Endometriosis is a chronic recurrent disease with insufficiently studied pathogenesis. Endometriosis is known to share similar features with tumors. Thus, the outgrowth of endometrium-like tissue outside the uterus is the main feature of th…

Angiogenesis is the development of new blood vessels from pre-existing ones. It is a complex multifaceted process that is essential for the adequate functioning of human organisms. The investigation of angiogenesis is conducted using variou…

Endometriosis is a chronic gynecological disease, which poses a serious problem in terms of diagnosis and treatment. Despite decades of research, there are no specific signs and symptoms and no blood tests to clinically confirm the diagnosi…

During pregnancy, uterine NK cells interact with trophoblast cells. In addition to contact interactions, uterine NK cells are influenced by cytokines, which are secreted by the cells of the decidua microenvironment. Cytokines can affect the…

Microvesicles (MVs) are plasma extracellular vesicles ranging from 100 (150) to 1000 nm in diameter. These are generally produced by different cells through their vital activity and are a source of various protein and non-protein molecules.…

Эндометриоз — это заболевание, характеризующееся иммунной дисфункцией на различных уровнях: от нарушений в передаче сигналов цитокинами к изменениям в популяциях клеток иммунной системы, в результате чего развивается персистирующая воспали…

Hypothesis/aims of study. Endometriosis is the main cause of infertility and social maladjustment in women, caused by the presence of inflammatory endometriotic implants outside the uterus. A number of chemokines, including interferons, com…

Angiogenesis is a process of new blood vessel formation, which plays a significant role in carcinogenesis and the development of diseases associated with pathological neovascularization. An important role in the regulation of angiogenesis b…

Endometriosis is a disease accompanied by development of heterotopic endometrial foci at the peritoneum, proliferation of endothelial cells, and inflammatory reaction. Aiming to specify the dynamics of inflammatory process in endometriosis …

65535 Endometriosis is a pelvic pathological process, when endometriotic lesions require neovascularisation to establish, proliferate and invide inside the peritoneal cavity. We analyzed the role of main angiogenic factors VEGF and bFGF in …

The concentrations of proinflammatory cytokines (IL-1beta, IL-6), vascular endothelium growth factor, tumor growth factor-beta, and insulin-like growth factor-1 were measured in the peritoneal fluid of patients with external genital endomet…

The article represents the authors data, gained during studies of systemic and local mechanisms of regulation of immune processes in pathogenesis of external genital endometriosis. Research was carried out into spectrum and production of so…