Evaluation of monocyte chemotactic protein-1 levels in peripheral blood of infertile women with endometriosis

Gmyrek GB, Grzegorz B. Gmyrek, Rafał Sozański, Rafal Sozanski, Sozanski R, Małgorzata Jerzak, Jerzak M, Malgorzata Jerzak, Agnieszka Chrobak, Dorota Wickiewicz, Wickiewicz D, Alicja Skupnik, Skupnik A, Sieradzka U, Urszula Sieradzka, Wojciech Fortuna, M Gabryś, Marian Gabrys, Anna Chełmońska‐Soyta, Chelmonska-Soyta A, Anna Chelmonska-Soyta
European journal of obstetrics, gynecology, and reproductive biology · 2005 · vol. 122(2) , pp. 199–205 · doi:10.1016/j.ejogrb.2005.03.019 · PMID:15893866 · W1998424234
Observational OA: closed CC0 ⤵ 39 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study measured monocyte chemotactic protein-1 levels in the peripheral blood of infertile women with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To test whether serum monocyte chemotactic protein-1 (MCP-1) chemokine levels correlate with endometriosis in infertile women. STUDY DESIGN: A group of women with endometriosis (n = 18, infertile) was compared with patients with uterine leiomyoma (n = 16, fertile), unexplained infertility (n = 5, infertile), and healthy women (n = 16, fertile). MCP-1 expression levels were evaluated by ELISA assay. The data obtained were statistically analyzed using the Mann-Whitney test. P-Values <0.05 were considered as significant. RESULTS: MCP-1 concentrations (median; range of values) in serum were as follows: women with endometriosis (221; 101-635 pg/ml), women with unexplained infertility (167, 114-234 pg/ml), women with uterine leiomyoma (137; 88-200 pg/ml), and healthy donors (123; 98-194 pg/ml). Significant differences were observed in the women with endometriosis compared with those with uterine leiomyoma (p = 0.02) and healthy donors (p = 0.002). Among the women with endometriosis, the level of significance in MCP-1 level at rAFS stages III-IV was higher than that at rAFS stages I-II compared with healthy donors and women with leiomyoma (p = 0.002 and p = 0.02, respectively). CONCLUSIONS: These data show that an increased level of MCP-1 can characterize infertile women with endometriosis. However, further studies are needed to be able to determine whether increased MCP-1 chemokine expression can be related to infertility or is a result of endometriosis progress.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Chemokine CCL2 Endometriosis Infertility, Female Adult Adult Biomarkers Biomarkers Biomarkers Chemokine CCL2 Chemokine CCL2 Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunosorbent Assay Female Female Humans Humans Infertility, Female Infertility, Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (43)

Cited by (39)

Source provenance

europepmc
last seen: 2026-10-09T06:09:53.026058+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:03:11.681822+00:00
unpaywall
last seen: 2026-10-09T06:36:44.367587+00:00
License: CC0 · commercial use OK