In Vitro Sperm Phagocytosis by Human Peritoneal Macrophages in Endometriosis‐Associated Infertility

Jha P, P. Jha, A Farooq, Farooq A, Ahmad Farooq, N Agarwal, Agarwal N, Buckshee K, K. Buckshee
American journal of reproductive immunology (New York, N.Y. : 1989) · 1996 · vol. 36(4) , pp. 235–237 · doi:10.1111/j.1600-0897.1996.tb00169.x · PMID:8911632 · W2018725007
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Peritoneal macrophages from infertile women with endometriosis showed higher concentrations and increased in vitro sperm phagocytosis compared to those without endometriosis.

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Abstract

PROBLEM: The mechanism of infertility in women with endometriosis remains obscure. In this context the role of peritoneal macrophage's sperm phagocytic ability in infertile women with and without endometriosis was investigated. METHOD: Analysis of peritoneal macrophage concentration and in vitro sperm phagocytosis in 10 infertile women with endometriosis and 10 infertile women without endometriosis was carried out. RESULTS: It was observed that infertile women with endometriosis are associated with higher concentration and higher sperm phagocytic activity of peritoneal macrophages than those without endometriosis. CONCLUSION: Despite the small number of women in this study, it may be concluded that the increased number of peritoneal macrophages coupled with enhanced in vitro sperm phagocytosis may disturb fertilization and thereby cause infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Macrophages, Peritoneal Phagocytosis Spermatozoa Endometriosis Endometriosis Female Humans Infertility, Female Macrophages, Peritoneal Male Spermatozoa

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (18)

Cited by (23)

SciLite annotations

organisms 1
human

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License: CC0 · commercial use OK