Peritoneal fluid prostaglandins in endometriosis, tubal disorders, and unexplained infertility.
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Peritoneal fluid concentrations of prostaglandins 6-keto-PGF1 alpha and thromboxane B2 were elevated in women with endometriosis, tubal disorders, or unexplained infertility compared to controls, irrespective of sex steroid levels or menstrual cycle day.
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Abstract
To elucidate the roles of prostaglandins in peritoneal fluid and sex steroids in patients with endometriosis (N = 29), tubal disorders (N = 15), and unexplained infertility (N = 13), assays were performed using 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) (a metabolite of prostacyclin), thromboxane B2 (a metabolite of thromboxane A2), estradiol, and progesterone. Women with normal pelvic anatomy (N = 25) served as controls. Peritoneal fluid 6-keto-PGF1 alpha concentrations in patients with endometriosis (742 +/- 104 pg/ml, mean +/- SE), tubal disorders (987 +/- 211 pg/ml), and unexplained infertility (1659 +/- 770 pg/ml) were higher than those in the control women (515 +/- 77 pg/ml). The thromboxane B2 levels in the peritoneal fluid in endometriosis (554 +/- 73 pg/ml), tubal disorders (614 +/- 107 pg/ml), and unexplained infertility (668 +/- 161 pg/ml) were higher than the levels in the control subjects (333 +/- 23 pg/ml). There was no relationship between 6-keto-PGF1 alpha/thromboxane B2 in peritoneal fluid and day of menstrual cycle. The concentrations of estradiol and progesterone were normal in all patient groups and were not related to the 6-keto-PGF1 alpha and thromboxane B2 levels. The authors suggest that these prostanoids, which may contribute to infertility, may originate mainly from the peritoneum as a result of irritation by endometriotic implants, tubal adhesions, and scarring.
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Cited by (26)
- Involvement of bradykinin and bradykinin B1 receptor in patients with endometriosis 2021
- Common and specific gene signatures among three different endometriosis subtypes 2020
- Abnormal Expression of Prostaglandins E2 and F2<i>α</i>Receptors and Transporters in Patients with Endometriosis 2015
- The effect of ovarian follicular fluid and peritoneal fluid on Fallopian tube ciliary beat frequency 2005
- Assessment of Fallopian Tube Cytology for the Diagnosis of Endometriosis and Hydrosalpinx. 2002
- Immunobiology of endometriosis 2001
- Pathophysiology of Endometriosis-Associated Infertility 1999
- Peritoneal Cellular Immunity and Endometriosis 1997
- In Vitro Sperm Phagocytosis by Human Peritoneal Macrophages in Endometriosis‐Associated Infertility 1996
- Serum from endometriosis patients impairs the development of mouse embryos <i>in vitro</i>— comparison with serum from tubal obstruction patient and plasmanate 1996
- Danazol versus [d-Trp6]GnRH agonist for the management of infertility due to atypical endometriosis 1996
- PGE2 and PGF2α release by human peritoneal macrophages in endometriosis 1996
- <i>In vitro</i> fertilization/embryo transfer in unexplained infertility and minimal peritoneal endometriosis 1995
- Changing concepts of medical treatment of endometriosis 1993
- The Lack of Effect of Tumor Necrosis Factor‐Alpha, Interleukin‐1‐Alpha, and Interferon‐Gamma on Human Sperm Motility In Vitro 1992
- Prostaglandins in Dysmenorrhoea and Endometriosis 1992
- Relationships between pelvic pain and prostaglandin levels in plasma and peritoneal fluid collected from women after sterilization 1992
- The endometrium and endometriosis 1991
- Elevated peritoneal fluid luteinizing hormone and prolactin concentrations in infertile women with endometriosis 1990
- Nafarelin in the treatment of infertility caused by endometriosis 1990
- Eicosanoids in primary dysmenorrhea, endometriosis and menstrual migraine 1989
- Uterine contractions in endometriosis: Effects of operative and danazol treatment 1988
- Effect of endometriosis on ovulation, ovum pickup, fertilization and tubal transport in the rabbit 1988
- Cul-de-sac fluid in women with endometriosis: fluid volume, protein and prostanoid concentration during the periovulatory period—days 13 to 18 1987
- Endometriosis, Lesions of the Secondary Müllerian System, and Pelvic Mesothelial Proliferations 1987
- Peritoneal fluid 6‐keto‐prostaglandin FL<sub>α</sub>, thromboxane B2 in endometriosis and unexplained infertility 1984
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