Immunology of Endometriosis and Immunotherapy

Emre Seli; Murat Berkkanoğlu; Aydın Arıcı; Neil Mahutte

doi:10.1201/b14235-8

Immunology of Endometriosis and Immunotherapy

Emre Seli, Murat Berkkanoğlu, Aydın Arıcı, Neil Mahutte

In: Endometriosis · 2003 · pp. 99–122 · doi:10.1201/b14235-8 · W2492053615

book-chapter OA: closed CC0 ⤵ 1 in-corpus citation

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review explores the complex interplay of the immune system in endometriosis and discusses potential immunotherapy targets for treatment.

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endometriosis

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References (100)

Aberrant integrin expression in the endometrium of women with endometriosis via openalex
Antibodies to Endometrial Transferrin and Alpha 2‐Heremans Schmidt (HS) Glycoprotein in Patients With Endometriosis via openalex
Antiendometrial antibodies in endometriosis measured by an enzyme-linked immunosorbent assay before and after treatment with danazol and nafarelin. via openalex
Autoimmunity in Endometriosis: Relevance to Infertility via openalex
Autoimmunity to endometrium and ovary in endometriosis. via openalex
Changes of peripheral blood lymphocyte subsets before and after operation of patients with endometriosis via openalex
Characterization of leukocyte subpopulations in the peritoneal fluid of women with endometriosis via openalex
Characterization of Lymphocyte Subpopulations and T Cell Activation In Endometriosis via openalex
Chronic gynecological conditions reported by US women: findings from the National Health Interview Survey, 1984 to 1992. via openalex
Comparative Effect of Danazol and a GnRH Agonist on Monocyte Chemotactic Protein‐1 Expression by Endometriotic Cells via openalex
Comparison of cytokine levels and embryo toxicity in peritoneal fluid in infertile women with untreated or treated endometriosis via openalex
Cytokine-induced secretion of monocyte chemotactic protein-1 by human endometriotic cells in culture via openalex
Danazol Suppresses Both Spontaneous and Activated Human Lymphocyte‐Mediated Cytotoxicity via openalex
Danazol Suppresses the Production of Interleukin‐1β and Tumor Necrosis Factor by Human Monocytes via openalex
Deficient cellular immunity in endometriosis via openalex
Early endometriosis invades the extracellular matrix via openalex
Early endometriosis invades the extracellular matrix via openalex
Ectopic endometrial cells express high concentrations of interleukin (IL)-8 in vivo regardless of the menstrual cycle phase and respond to oestradiol by up-regulating IL-1-induced IL-8 expression in vitro via openalex
Effect of hormonal agents on monocyte chemotactic protein-1 expression by endometrial epithelial cells of women with endometriosis via openalex
Effect of interleukin-1 on gamete interaction and mouse embryo development. via openalex
Effect of Peritoneal Fluid From Endometriosis Patients on Endometrial Stromal Cell Proliferation In Vitro via openalex
Effect of peritoneal fluid from women with endometriosis on implantation in the mouse model via openalex
Effect of tumor necrosis factor-α on adhesion of human endometrial stromal cells to peritoneal mesothelial cells: an in vitro system via openalex
Elevated expression of tumour necrosis factor α in cultured granulosa cells from women with endometriosis via openalex
Endocrinology and paracrinology via openalex
ENDOMETRIOSIS via openalex
Endometriosis: pathogenetic implications of the anatomic distribution. via openalex
Estradiol Amplifies Interleukin-1-Induced Monocyte Chemotactic Protein-1 Expression by Ectopic Endometrial Cells of Women with Endometriosis via openalex
Expression of intercellular adhesion molecule (ICAM)-1 mRNA and protein is enhanced in endometriosis versus endometrial stromal cells in culture via openalex
Fresh mouse peritoneal macrophages have low scavenger receptor activity via openalex
HOX gene expression is altered in the endometrium of women with endometriosis via openalex
IL‐1β TNF‐α, and IL‐2 in Peritoneal Fluid and Macrophage‐Conditioned Media of Women With Endometriosis via openalex
Immune rosettes of T and B lymphocytes in infertile women with endometriosis. via openalex
Immunobiology of endometriosis via openalex
Immunolocalisation of Vascular Endothelial Growth Factor in Human Endometrium via openalex
Immunological factors in endometriosis-associated reproductive failure: studies in fertile and infertile women with and without endometriosis via openalex
Immunologic Aspects of Human Endometriosis via openalex
Immunomodulation in the treatment of endometriosis-associated subfertility: use of pentoxifylline to reverse the inhibition of fertilization by surgically induced endometriosis a rodent model via openalex
Immunomodulation in women with endometriosis receiving GnRH agonist via openalex
Immunosuppressive activity of peritoneal fluid in women with endometriosis. via openalex
Immunosuppressive effects of danazol in vitro via openalex
Increased Expression of Monocyte Chemotactic Protein-1 in the Endometrium of Women With Endometriosis via openalex
Increased killer inhibitory receptor KIR2DL1 expression among natural killer cells in women with pelvic endometriosis via openalex
Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1 via openalex
Interleukin-1: a possible role in the infertility associated with endometriosis via openalex
Interleukin‐1: A possible role in the infertility associated with endometriosis via openalex
Interleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin via openalex
In Vitro Sperm Phagocytosis by Human Peritoneal Macrophages in Endometriosis‐Associated Infertility via openalex
Is endornetriosis an autoimmune disease via openalex
Local Cytokines in Endometrial Tissue: The Role of Interleukin‐8 in the Pathogenesis of Endometriosis via openalex
Lymphocyte activity in the presence of peritoneal fluid from fertile women and infertile women with and without endometriosis via openalex
Lymphocyte subsets in endometriosis. via openalex
Moderate and severe endometriosis is associated with alterations in the cell cycle of granulosa cells in patients undergoing in vitro fertilization and embryo transfer via openalex
Monocyte-mediated enhancement of endometrial cell proliferation in women with endometriosis via openalex
Natural cytotoxicity and gnrh agonist administration in advanced endometriosis: positive modulation on natural killer activity via openalex
Ovarian Dysfunction in Endometriosis-Associated and Unexplained Infertility via openalex
Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis via openalex
Pentoxifylline versus placebo in the treatment of infertility associated with minimal or mild endometriosis: a pilot randomized clinical trial via openalex
Peritoneal Cellular Immunity and Endometriosis via openalex
Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex
Peritoneal fluid concentrations of the cytokine RANTES correlate with the severity of endometriosis via openalex
Peritoneal fluid eicosanoids in chronic pelvic pain via openalex
Peritoneal Fluid lnterleukin‐1β and Tumor Necrosis Factor in Patients With Benign Gynecologic Disease via openalex
Peritoneal macrophages and infertility: the association between cell number and pelvic pathology via openalex
Peritoneal natural killer cytotoxicity and CD25+CD3+ lymphocyte subpopulation are decreased in women with stage III–IV endometriosis via openalex
PGE2 and PGF2α release by human peritoneal macrophages in endometriosis via openalex
Recombinant human TNF binding protein-1 (r-hTBP-1) inhibits the development of endometriosis in baboons: a prospective, randomized, placebo- and drug-controlled study. via openalex
Relationships Between Concentrations of Tumor Necrosis Factor-α and Nitric Oxide in Follicular Fluid and Oocyte Quality via openalex
Reproductive failure because of autoantibodies: Unexplained infertility and pregnancy wastage via openalex
Retrograde menstruation in healthy women and in patients with endometriosis. via openalex
Retrograde menstruation in women undergoing chronic peritoneal dialysis. via openalex
Retrograde Seeding of Endometrium: A Sequela of Tubal Flushing via openalex
Suppression of natural killer cell activity by sera from patients with endometriosis via openalex
The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro via openalex
The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production via openalex
Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. via openalex
W4250972286 via openalex
W11141567 via openalex
W98045151 via openalex
W141728048 via openalex
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W1453987920 via openalex
W1532278869 via openalex
W1538068696 via openalex
W1965369938 via openalex
W1971586374 via openalex
W1980609937 via openalex
W2001265245 via openalex
W2015629565 via openalex
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W2048027016 via openalex
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W2098130458 via openalex

Cited by (1)

Zur Bedeutung der Endometriose in der Reproduktionsmedizin 2007

Source provenance

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[1] Aberrant integrin expression in the endometrium of women with endometriosis via openalex

[2] Antibodies to Endometrial Transferrin and Alpha 2‐Heremans Schmidt (HS) Glycoprotein in Patients With Endometriosis via openalex

[3] Antiendometrial antibodies in endometriosis measured by an enzyme-linked immunosorbent assay before and after treatment with danazol and nafarelin. via openalex

[4] Autoimmunity in Endometriosis: Relevance to Infertility via openalex

[5] Autoimmunity to endometrium and ovary in endometriosis. via openalex

[6] Changes of peripheral blood lymphocyte subsets before and after operation of patients with endometriosis via openalex

[7] Characterization of leukocyte subpopulations in the peritoneal fluid of women with endometriosis via openalex

[8] Characterization of Lymphocyte Subpopulations and T Cell Activation In Endometriosis via openalex

[9] Chronic gynecological conditions reported by US women: findings from the National Health Interview Survey, 1984 to 1992. via openalex

[10] Comparative Effect of Danazol and a GnRH Agonist on Monocyte Chemotactic Protein‐1 Expression by Endometriotic Cells via openalex

[11] Comparison of cytokine levels and embryo toxicity in peritoneal fluid in infertile women with untreated or treated endometriosis via openalex

[12] Cytokine-induced secretion of monocyte chemotactic protein-1 by human endometriotic cells in culture via openalex

[13] Danazol Suppresses Both Spontaneous and Activated Human Lymphocyte‐Mediated Cytotoxicity via openalex

[14] Danazol Suppresses the Production of Interleukin‐1β and Tumor Necrosis Factor by Human Monocytes via openalex

[15] Deficient cellular immunity in endometriosis via openalex

[16] Early endometriosis invades the extracellular matrix via openalex

[17] Early endometriosis invades the extracellular matrix via openalex

[18] Ectopic endometrial cells express high concentrations of interleukin (IL)-8 in vivo regardless of the menstrual cycle phase and respond to oestradiol by up-regulating IL-1-induced IL-8 expression in vitro via openalex

[19] Effect of hormonal agents on monocyte chemotactic protein-1 expression by endometrial epithelial cells of women with endometriosis via openalex

[20] Effect of interleukin-1 on gamete interaction and mouse embryo development. via openalex

[21] Effect of Peritoneal Fluid From Endometriosis Patients on Endometrial Stromal Cell Proliferation In Vitro via openalex

[22] Effect of peritoneal fluid from women with endometriosis on implantation in the mouse model via openalex

[23] Effect of tumor necrosis factor-α on adhesion of human endometrial stromal cells to peritoneal mesothelial cells: an in vitro system via openalex

[24] Elevated expression of tumour necrosis factor α in cultured granulosa cells from women with endometriosis via openalex

[25] Endocrinology and paracrinology via openalex

[26] ENDOMETRIOSIS via openalex

[27] Endometriosis: pathogenetic implications of the anatomic distribution. via openalex

[28] Estradiol Amplifies Interleukin-1-Induced Monocyte Chemotactic Protein-1 Expression by Ectopic Endometrial Cells of Women with Endometriosis via openalex

[29] Expression of intercellular adhesion molecule (ICAM)-1 mRNA and protein is enhanced in endometriosis versus endometrial stromal cells in culture via openalex

[30] Fresh mouse peritoneal macrophages have low scavenger receptor activity via openalex

[31] HOX gene expression is altered in the endometrium of women with endometriosis via openalex

[32] IL‐1β TNF‐α, and IL‐2 in Peritoneal Fluid and Macrophage‐Conditioned Media of Women With Endometriosis via openalex

[33] Immune rosettes of T and B lymphocytes in infertile women with endometriosis. via openalex

[34] Immunobiology of endometriosis via openalex

[35] Immunolocalisation of Vascular Endothelial Growth Factor in Human Endometrium via openalex

[36] Immunological factors in endometriosis-associated reproductive failure: studies in fertile and infertile women with and without endometriosis via openalex

[37] Immunologic Aspects of Human Endometriosis via openalex

[38] Immunomodulation in the treatment of endometriosis-associated subfertility: use of pentoxifylline to reverse the inhibition of fertilization by surgically induced endometriosis a rodent model via openalex

[39] Immunomodulation in women with endometriosis receiving GnRH agonist via openalex

[40] Immunosuppressive activity of peritoneal fluid in women with endometriosis. via openalex

[41] Immunosuppressive effects of danazol in vitro via openalex

[42] Increased Expression of Monocyte Chemotactic Protein-1 in the Endometrium of Women With Endometriosis via openalex

[43] Increased killer inhibitory receptor KIR2DL1 expression among natural killer cells in women with pelvic endometriosis via openalex

[44] Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1 via openalex

[45] Interleukin-1: a possible role in the infertility associated with endometriosis via openalex

[46] Interleukin‐1: A possible role in the infertility associated with endometriosis via openalex

[47] Interleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin via openalex

[48] In Vitro Sperm Phagocytosis by Human Peritoneal Macrophages in Endometriosis‐Associated Infertility via openalex

[49] Is endornetriosis an autoimmune disease via openalex

[50] Local Cytokines in Endometrial Tissue: The Role of Interleukin‐8 in the Pathogenesis of Endometriosis via openalex

[51] Lymphocyte activity in the presence of peritoneal fluid from fertile women and infertile women with and without endometriosis via openalex

[52] Lymphocyte subsets in endometriosis. via openalex

[53] Moderate and severe endometriosis is associated with alterations in the cell cycle of granulosa cells in patients undergoing in vitro fertilization and embryo transfer via openalex

[54] Monocyte-mediated enhancement of endometrial cell proliferation in women with endometriosis via openalex

[55] Natural cytotoxicity and gnrh agonist administration in advanced endometriosis: positive modulation on natural killer activity via openalex

[56] Ovarian Dysfunction in Endometriosis-Associated and Unexplained Infertility via openalex

[57] Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis via openalex

[58] Pentoxifylline versus placebo in the treatment of infertility associated with minimal or mild endometriosis: a pilot randomized clinical trial via openalex

[59] Peritoneal Cellular Immunity and Endometriosis via openalex

[60] Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex

[61] Peritoneal fluid concentrations of the cytokine RANTES correlate with the severity of endometriosis via openalex

[62] Peritoneal fluid eicosanoids in chronic pelvic pain via openalex

[63] Peritoneal Fluid lnterleukin‐1β and Tumor Necrosis Factor in Patients With Benign Gynecologic Disease via openalex

[64] Peritoneal macrophages and infertility: the association between cell number and pelvic pathology via openalex

[65] Peritoneal natural killer cytotoxicity and CD25+CD3+ lymphocyte subpopulation are decreased in women with stage III–IV endometriosis via openalex

[66] PGE2 and PGF2α release by human peritoneal macrophages in endometriosis via openalex

[67] Recombinant human TNF binding protein-1 (r-hTBP-1) inhibits the development of endometriosis in baboons: a prospective, randomized, placebo- and drug-controlled study. via openalex

[68] Relationships Between Concentrations of Tumor Necrosis Factor-α and Nitric Oxide in Follicular Fluid and Oocyte Quality via openalex

[69] Reproductive failure because of autoantibodies: Unexplained infertility and pregnancy wastage via openalex

[70] Retrograde menstruation in healthy women and in patients with endometriosis. via openalex

[71] Retrograde menstruation in women undergoing chronic peritoneal dialysis. via openalex

[72] Retrograde Seeding of Endometrium: A Sequela of Tubal Flushing via openalex

[73] Suppression of natural killer cell activity by sera from patients with endometriosis via openalex

[74] The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro via openalex

[75] The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production via openalex

[76] Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. via openalex

[77] W4250972286 via openalex

[78] W11141567 via openalex

[79] W98045151 via openalex

[80] W141728048 via openalex

[81] W207739235 via openalex

[82] W1453987920 via openalex

[83] W1532278869 via openalex

[84] W1538068696 via openalex

[85] W1965369938 via openalex

[86] W1971586374 via openalex

[87] W1980609937 via openalex

[88] W2001265245 via openalex

[89] W2015629565 via openalex

[90] W2017967258 via openalex

[91] W2024456541 via openalex

[92] W2032894856 via openalex

[93] W2035816658 via openalex

[94] W2048027016 via openalex

[95] W2054556903 via openalex

[96] W2056242981 via openalex

[97] W2083056555 via openalex

[98] W2083255112 via openalex

[99] W2090152451 via openalex

[100] W2098130458 via openalex