Effect of interleukin-1 on gamete interaction and mouse embryo development.

Carlos Sueldo, C E Sueldo, E Kelly, Elizabeth F. Kelly, L Montoro, Luís Montoro, Luis Montoro, E Subias, Elisabet Subias, Miguel Baccaro, M Baccaro, J A Swanson, Jim Swanson, Alex Steinleitner, A Steinleitner, Hovey Lambert, H Lambert
The Journal of reproductive medicine · 1990 · vol. 35(9) , pp. 868–72 · PMID:2231560 · W170358168
article OA: closed CC0 ⤵ 19 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

Interleukin-1 impairs sperm-egg interaction in the SPA and ZPPA and inhibits early mouse embryo development, potentially explaining subfertility in endometriosis.

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Abstract

Early stages of endometriosis have been shown to be associated with infertility. The pathophysiology of this relationship is unclear. To determine if interleukin-1 (IL-1), a peritoneal macrophage product, has any effect on gamete interaction and early embryo development, human recombinant IL-1 was added to the coincubation of gametes in the sperm penetration assay (SPA), human zona pellucida assay (ZPPA) and culture medium (Ham's F-10) used for processing semen samples with the layering method, with analysis of velocity and motility after 24 hours. IL-1 was also added to mouse embryos (two cells) cultured for 72 hours. The results showed that IL-1 caused impairment of SPA and ZPPA when compared to control medium, without significant alterations in sperm velocity and motility. Also, IL-1 demonstrated significant inhibition of mouse embryo development. These results help explain subfertility associated with early stages of endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Embryonic and Fetal Development Endometriosis Interleukin-1 Sperm-Ovum Interactions Animals Ascitic Fluid Ascitic Fluid Endometriosis Female Infertility, Female Infertility, Female Interleukin-1 Male Mice Peritoneum Pregnancy Sperm Motility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (19)

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