Outcome of IVF in Patients with Endometriosis in Comparison with Tubal-Factor Infertility

Annica Bergendal, A Bergendal, Bergendal A, Naffah S, S Naffah, Sophie Naffah, C Nagy, Nagy C, Christina Nagy, Bergqvist A, A Bergqvist, Agneta Bergqvist, P Sjöblom, Sjöblom P, Peter Sjöblom, T Hillensjö, Torbjörn Hillensjø, Hillensjö T
Journal of assisted reproduction and genetics · 1998 · vol. 15(9) , pp. 530–534 · doi:10.1023/a:1022526002421 · PMID:9822979 · PMC3454921 · W1496427670
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⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-06-11 ⓘ

This retrospective study found that women with endometriosis undergoing IVF had significantly lower fertilization rates compared to tubal-factor infertility controls, but similar implantation and pregnancy rates.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This retrospective study compared IVF and embryo transfer outcomes in 48 women with endometriosis (65 cycles) versus a matched control group of 98 cycles from 98 women with tubal-factor infertility, assessing stimulation, fertilization, embryo development, implantation, and pregnancy outcomes. The key finding was a significantly lower fertilization rate in the endometriosis group, while cleavage, implantation, and pregnancy rates did not differ between groups. The authors’ main caveat is that the analysis is retrospective and focuses on cycle-level outcomes without prospectively controlling for all potential confounders. This paper is centrally about endometriosis — it evaluates IVF outcomes in women with endometriosis compared with tubal-factor infertility.

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Abstract

PurposeThe aim of this retrospective study was to compare the outcome of in vitro fertilization and embryo transfer in women with endometriosis and a control group with tubal-factor infertility.MethodsForty-eight patients with endometriosis underwent 65 cycles of in vitro fertilization and embryo transfer at Huddinge University Hospital. The matched control group with tubal-factor infertility consisted of 98 cycles in 98 patients. These groups were retrospectively analyzed regarding stimulation, fertilization, embryo development, implantation, and pregnancy outcome.ResultsThe fertilization rate was significantly lower in women with endometriosis, but the cleavage, implantation, and pregnancy rates did not differ.ConclusionsOur results show that women with endometriosis have a lower fertilization rate compared with women with tubal-factor infertility. However, once the oocyte is fertilized, it seems that the preembryo has a normal chance of implantation, leading to similar pregnancy rates.
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Abstract

Purpose: The aim of this retrospective study was to compare the outcome of in vitro fertilization and embryo transfer in women with endometriosis and a control group with tubal-factor infertility.

Methods

Forty-eight patients with endometriosis underwent 65 cycles of in vitro fertilization and embryo transfer at Huddinge University Hospital. The matched control group with tubal-factor infertility consisted of 98 cycles in 98 patients. These groups were retrospectively analyzed regarding stimulation, fertilization, embryo development, implantation, and pregnancy outcome.

Results

The fertilization rate was significantly lower in women with endometriosis, but the cleavage, implantation, and pregnancy rates did not differ.

Conclusions

Our results show that women with endometriosis have a lower fertilization rate compared with women with tubal-factor infertility. However, once the oocyte is fertilized, it seems that the preembryo has a normal chance of implantation, leading to similar pregnancy rates. Similar content being viewed by others

References

Arici A, Oral E, Bukulmez O, Duleba A, Olive DL, Jones EE: The effect of endometriosis on implantation: results from the Yale University in vitro fertilization and embryo transfer program. Fertil Steril 1996;65:603-607 Hill JA: Immunologic factors in endometriosis and endometriosis-associated reproductive failure. Infert Reprod Med Clin North Am 1992;3:583-596 Gleicher N: Endometriosis, a new approach is needed. Hum Reprod 1992;7:821-824 Shushan A, Eisenberg VH, Schenker JG: Subfertility in the era of assisted reproduction: Changes and consequences. Fertil Steril 1995;64:459-469 Mahmood TA, Arumugam K, Templeton AA: Oocyte and follicular fluid characteristics in women with mild endometriosis. Br J Obstet Gynecol 1991;8:573-577 Olivennes F, Feldberg D, Liu HC, Cohen J, Moy F, Rosenwaks Z: Endometriosis: A stage by stage analysis-the role of in vitro fertilization. Fertil Steril 1995;64:392-398 Geber S, Paraschos T, Atkinson G, Margara R, Winston RML: Results of IVF in patients with endometriosis: The severity of the disease does not affect the outcome, or the incidence of miscarriage. Hum Reprod 1995;10:1507-1511 Wardle PG, McLaughlin EA, McDermot A, Mitchell JD, Ray BD, Hull MGR: Endometriosis and ovulatory disorder: reduced fertilization in vitro compared with tubal and unexplained infertility. Lancet 1985;2:236-239 Yovich JL, Yovich JM, Tuvik AI, Matson PL, Willcox DL: In-vitro fertilization for endometriosis. Lancet 1985;2:552 (Letter) O'Shea RT, Chen C, Weiss T, Jones WR: Endometriosis and in-vitro fertilization. Lancet 1985;2:723.8 (Letter) Wardle PG, Foster PA, Mitchell JD, McLaughlin EA, Sykes JA, Corrigan E, Hull MG, Ray BD, McDermott A: Endometriosis and IVF: Effect of prior therapy. Lancet 1986;1:276-277 Badaway SZA, Cuenca V, Marshall L, Munchback R, Rinas AC, Coble DA: Cellular components in peritoneal fluid in infertile patients with and without endometriosis. Fertil Steril 1984;42:704-708 Halme J, Becher S, Hammond M, Raj HMG, Raj S: Increased activation of pelvic macrophages in infertile women with mild endometriosis. Am J Obstet Gynecol 1983;145:333-337 Olive DL, Weinberg JB, Haney AF: Peritoneal macrophages and infertility: The association between cell number and pelvic pathology. Fertil Steril 1985;44:772-777 Dunselman GAJ, Hendrix MGR, Bouckaert PXJM, Evers JLH: Functional aspects of peritoneal macrophages in endometriosis of women. J Reprod Fertil 1988;82:707-710 Anderson DJ, Hill JA: Cell-mediated immunity in infertility. Am J Reprod Immunol Microbiol 1988;17:22-30 Sueldo CE, Lambert H, Steinleitner A, Rathwick, G, Swanson JA: The effect peritoneal fluid from patients with endometriosis on murine sperm-oocyte interaction. Fertil Steril 1987;48:697-699 Akoum A, Lemay A, Paradis I., Rheault N, Maheux R: Secretion of interleuikin-6 by human endometric cells and regulation by proinflammatory cytokines and sex steroids. Hum Reprod 1996;11:2269-2275 Bergquist A, Nejaty H, Fröjsa B, Bruce C, Sjöblom P, Söder O. Production of interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor (TNF) α in separated and cultured stromal and epithelial cells from endometriotic tissue and endometriosis. Mol Human Reprod 1998. (accepted for publication) Rana N, Braun DP, House R, Gebel H, Rotman C, Dmowski WP: Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis. Fertil Steril 1996;65:925-930 Sueldo CE, Kelly E, Montoro L, Subias E, Baccaro M, Swanson J, Steinleitner A, Lambert H: Effect of interleukin-1 on gamete interaction and mouse embryo development. J Reprod Med 1990;35:868-872 Tasdemir M, Tasdemir I, Kodama H, Tanaka T: Effect of peritoneal fluid from infertile women with endometriosis on ionophore-stimulated acrosome loss. Hum Reprod 1995;10:2419-2422 Arumugam K: Endometriosis and fertility: Raised iron concentration in the peritoneal fluid and its effect on the acrosome reaction. Hum Reprod 1994;9:1153-1157 Aeby TC, Huang T, Nakayama RT: The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro. Am J Obstet Gynecol 1996;174:1779-1783 Steinleitner A, Lambert H, Roy S: Immunomodulation with pentoxifylline abrogates macrophage-mediated infertility in an in vivo model: A paradigm for a novel approach to the treatment of endometriosis-associated subfertility. Fertil Steril 1991;55:26-31 Tanbo T, Omland A, Dale PO, Abyholm T: In vitro fertilization/embryo transfer in unexplained infertility and minimal peritoneal endometriosis. Acta Obstet Gynecol Scand 1995;74:539-543 Brizek CL, Schlaff S, Pellegrini VA, Frank JB, Worrilow KC: Increased incidence of aberrant morphological phenotypes in human embryogenesis—an association with endometriosis. J Assist Reprod Genet 1995;12:106-112 Gutiérrez A, Oliveira N, Cano F, Ruiz A, Simon C, Remohi J, Pellicer A: In vitro fertilization in infertile patients with endometriosis. Assist Reprod Rev 1994;4:162-171 Dmowski WP: Immunological aspects of endometriosis. Int J Gynecol Obstet 1995;50(Suppl. 1):3-10 Simón C, Gutiérrez A, Vidal A, de los Santos MJ, Tarin JJ, Remohi J, Pellicer A: Outcome of patients with endometriosis in assisted reproduction: Results from in-vitro fertilization and oocyte donation. Hum Reprod 1994;9:725-729 Palmisano GP, Adamson GD, Lamb EJ. Can staging systems for endometriosis based on anatomic location and lesion type predict pregnancy rates? Int J Fertil 1993;38:241-249 Author information Authors and Affiliations Rights and permissions About this article Cite this article Bergendal, A., Naffah, S., Nagy, C. et al. Outcome of IVF in Patients with Endometriosis in Comparison with Tubal-Factor Infertility. J Assist Reprod Genet 15, 530–534 (1998). https://doi.org/10.1023/A:1022526002421 Issue date: DOI: https://doi.org/10.1023/A:1022526002421

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Fertilization in Vitro Infertility, Female Pregnancy Outcome Adult Embryo Implantation Embryo Implantation Embryo Transfer Endometriosis Fallopian Tube Diseases Fallopian Tube Diseases Fallopian Tube Diseases Female Humans Infertility, Female Infertility, Female Infertility, Female Male Pregnancy Retrospective Studies

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