Implantation failures in women with infertility associated endometriosis

Victor Yevseyevich Radzinsky, Mekan Rakhimberdievich Orazov, Mekan R. Orazov, Igor Isaakovich Ivanov, I Ivanov, М.Б. Хамошина, Marina Borisovna Khamoshina, Igor Nikolaevich Kostin, И. Н. Костин, E. V. Kavteladze, Elena Varlamovna Kavteladze, Victoriya Borisovna Shustova
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2019 · vol. 35(sup1) , pp. 27–30 · doi:10.1080/09513590.2019.1632089 · PMID:31532313 · W2973770183
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This study found that women with endometriosis-associated infertility had a significantly lower implantation rate during IVF compared to women with tubal factor infertility, despite comparable embryo quality.

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Abstract

Endometriosis is currently considered as one of the most common diseases associated with infertility. A controversial issue is whether endometriosis per se exerts a detrimental effect on IVF outcomes. Failure of implantation due to endometriosis-associated infertility is a contradictory and widely discussed burden nowadays. The purpose of the study is to assess the quality of embryos and implantation rate in women with infertility associated with endometriosis. The study included infertile reproductive aged women, between 26 and 40 years who underwent IVF and ICSI procedures. The patients were divided into two groups: group I (n = 70) involved 70 patients with recurrent unilateral endometriomas, II control group (n = 50) with tubal factor infertility. The quality of the retrieved embryos was assessed according to the generally accepted classification of Gardner, indicating the rate of implantation in each group. Embryo transfer was performed in case of high quality embryos. Assessing the ovarian reserve indicators, in the group I patients with recurrent unilateral endometriomas the serum level of AMH was significantly lower (2.1 ± 1.75 vs. 3.2 ± 1.4, p < .005), as well as the number of retrieved oocytes (8.1 ± 3.9 and 10.1 ± 6.8, p < .005). The analysis of the results demonstrated that the duration of stimulation in the group patients with recurrent unilateral endometriomas was significantly higher in comparison with the group II (12.2 ± 1.8 and 10.2 ± 1.6 days, p < .001). Nevertheless, the number of good quality embryos retrieved was comparable in both groups (2.2 ± 1.5 and 2.8 ± 1.8). In the group I patients with recurrent unilateral endometriomas, there was a statistically significant decrease of implantation rate (17.1% vs. 24% p < .005). The results of the study revealed no statistical difference in embryo quality in the study cohort. However, it is important to note that a statistically significant difference in implantation rate in the group of endometriosis-associated infertility compared was obtained 1.5 times lower than in the control group (15.8% vs. 24.0% p < .005). The achieved results demonstrated an adverse IVF outcome in infertile women with recurrent endometrioma compared to the control group.

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Condition tags

endometriosisendometriomainfertility

MeSH descriptors

Abortion, Habitual Embryo Implantation Embryo Implantation Embryo Loss Endometriosis Infertility, Female Uterine Diseases Abortion, Habitual Abortion, Habitual Abortion, Habitual Adult Case-Control Studies Embryo Loss Embryo Loss Embryo Loss Endometriosis Endometriosis Endometriosis Female Fertilization in Vitro

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