Folate Metabolism Abnormalities in Infertile Patients with Endometriosis

Tarciana Oliveira Guedes, Aline Amaro dos Santos, Felipe H Vieira-Neto, Caio Parente Barbosa, Bianca Bianco, Denise Maria Christofolini
Biomarkers in medicine · 2022 · vol. 16(7) , pp. 549–557 · doi:10.2217/bmm-2021-0076 · PMID:35332781 · W4220900032
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MTHFR, MTR, and MTRR gene variants and their association with homocysteine levels, oocyte retrieval, and pregnancy outcomes were analyzed in infertile patients with endometriosis and controls.

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Abstract

Background: Homocysteine levels can be impacted by enzymes variations. Aim: To correlate MTHFR, MTR and MTRR variants with homocysteine levels in the blood and follicular fluid and assisted reproduction results. Material & methods: MTHFR (rs2274976, rs1801131, rs1801133), MTR (rs1805087) and MTRR (rs1801394) genotyping was performed by TaqMan assays and compared with homocysteine levels, measured by ELISA, to oocytes retrieved and to the pregnancy status of women with endometriosis and controls. Results: The MTR G allele and GG genotype were more common in patients with endometriosis. They also showed lower levels of homocysteine and more clinical gestations. Epistasis analysis showed a model associated with gestational results, composed of MTHFR+MTR variants (CC+AG). Conclusion: The summation effect of variants in genes participating in folate metabolism was associated with pregnancy status in Brazilian women. MTR variants were more observed in endometriosis patients, as well as lower follicular Hcy levels and increased clinical pregnancy results.

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Condition tags

endometriosis

MeSH descriptors

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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