Physiological characteristics of reproductive-age patients with female sexual dysfunction and endometriosis (a comparison of clinical and laboratory parameters in different study groups)

and methods. The examination results of the hormonal profile, sexual functional index and other laboratory markers were analyzed in 130 women of active reproductive age: Group I (n = 100) – the main group – women with manifestations of FSD including subgroup IA (n = 70) – women with FSD and external genital endometriosis and IB subgroup (n = 30) – women with FSD alone; Group II (n = 30) – healthy women. Results. Women with endometriosis combined with FSD (IA) exhibited a reproductive hormonal profile different from that in women with FSD (IB), which was seen by a significant difference in follicle-stimulating hormone (FSH), estradiol, free testosterone and dehydroepiandrosterone sulfate values (p = 0.001, p = 0.039, p = 0.035 and p = 0.035, respectively). Vitamin D deficiency and hyperhomocysteinemia, the presence of antibodies to thyroperoxidase and functional hyperprolactinemia have been detected in all the women with FSD signs, regardless of the concomitant endometriosis presence. Post-hoc analysis (Mann–Whitney test) has shown that the mean scores for all categories of the Female Sexual Function Index (FSFI) questionnaire were statistically significantly higher in Group IA patients compared to those in Group II patients (p < 0.001). Conclusions. The hormonal profile of women with endometriosis is characterized by increased levels of FSH, estradiol, free testosterone and dehydroepiandrosterone sulfate as compared to that in women with FSD alone, however it does not prevent the development of FSD signs in them and is accompanied by different indicators of the FSFI domains.

- Tan J, Taskin O, Iews M, Lee AJ, Kan A, Rowe T, et al. Atherosclerotic cardiovascular disease in women with endometriosis: a systematic review of risk factors and prospects for early surveillance. Reprod Biomed Online. 2019;39(6):1007-16. doi: https://doi.org/10.1016/j.rbmo.2019.05.021 - Tsamantioti ES, Mahdy H. Endometriosis. [Updated 2023 Jan 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK567777/ - Paulo Leonardo-Pinto J, Laguna Benetti-Pinto C, Angerame Yela D. When Solving Dyspareunia Is Not Enough to Restore Sexual Function in Women with Deep Infiltrating Endometriosis Treated with Dienogest. J Sex Marital Ther. 2019;45(1):44-9. doi: https://doi.org/10.1080/0092623X.2018.1474411 - Zondervan KT, Becker CM, Missmer SA. Endometriosis. N Engl J Med. 2020;382(13):1244-56. doi: https://doi.org/10.1056/NEJMra1810764 - Pérez-López FR, Ornat L, Pérez-Roncero GR, López-Baena MT, Sánchez-Prieto M, Chedraui P. The effect of endometriosis on sexual function as assessed with the Female Sexual Function Index: systematic review and meta-analysis. Gynecol Endocrinol. 2020;36(11):1015-23. doi: https://doi.org/10.1080/09513590.2020.1812570 - Rossi V, Galizia R, Tripodi F, Simonelli C, Porpora MG, Nimbi FM. Endometriosis and Sexual Functioning: How Much Do Cognitive and Psycho-Emotional Factors Matter? Int J Environ Res Public Health. 2022;19(9):5319. doi: https://doi.org/10.3390/ijerph19095319 - Xie B, Liao M, Huang Y, Hang F, Ma N, Hu Q, et al. Association between vitamin D and endometriosis among American women: National Health and Nutrition Examination Survey. PLoS One. 2024;19(1):e0296190. doi: https://doi.org/10.1371/journal.pone.0296190 - Guedes T, Santos AA, Vieira-Neto FH, Bianco B, Barbosa CP, Christofolini DM. Folate metabolism abnormalities in infertile patients with endometriosis. Biomark Med. 2022;16(7):549-57. doi: https://doi.org/10.2217/bmm-2021-0076 - Rafi U, Ahmad S, Bokhari SS, Iqbal MA, Zia A, Khan MA, et al. Association of Inflammatory Markers/Cytokines with Cardiovascular Risk Manifestation in Patients with Endometriosis. Mediators Inflamm. 2021;2021:3425560. doi: https://doi.org/10.1155/2021/3425560 - Both S, Lew-Starowicz M, Luria M, Sartorius G, Maseroli E, Tripodi F, et al. Hormonal Contraception and Female Sexuality: Position Statements from the European Society of Sexual Medicine (ESSM). J Sex Med. 2019;16(11):1681-95. doi: https://doi.org/10.1016/j.jsxm.2019.08.005 - World Health Organization (WHO). International classification of diseases (ICD-11). ICD-11 for motality and morbity statistics [Internet]. Geneva: WHO; 2021 [cited 2024 May 2]. Available from: https://icd.who.int/browse11 - Pashko AO. Statystychnyi analiz danykh [Statistical data analysis]. Taras Shevchenko National University of Kyiv: Kyiv; 2019 [cited 2024 May 2]. Ukrainian. Available from: https://csc.knu.ua/media/filer_public/19/d5/19d56780-269a-4eef-bb3b-48ec8da23859/intelektualnaobrobkadanikh.pdf - Abdelsamea GA, Amr M, Tolba AM, Elboraie HO, Soliman A, Al-Amir Hassan B, et al. Impact of weight loss on sexual and psychological functions and quality of life in females with sexual dysfunction: A forgotten avenue. Front Psychol. 2023;14:1090256. doi: https://doi.org/10.3389/fpsyg.2023.1090256 - Romero-Gómez B, Guerrero-Alonso P, Carmona-Torres JM, Laredo-Aguilera JA, Pozuelo-Carrascosa DP, Cobo-Cuenca AI. Sexual Function in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control. Int J Environ Res Public Health. 2020;17(12):4325. doi: https://doi.org/10.3390/ijerph17124325 - Bates JN, Kohn TP, Pastuszak AW. Effect of Thyroid Hormone Derangements on Sexual Function in Men and Women. Sex Med Rev. 2020;8(2):217-30. doi: https://doi.org/10.1016/j.sxmr.2018.09.005 - Gabrielson AT, Sartor RA, Hellstrom WJ. The Impact of Thyroid Disease on Sexual Dysfunction in Men and Women. Sex Med Rev. 2019;7(1):57-70. doi: https://doi.org/10.1016/j.sxmr.2018.05.002 Downloads Published How to Cite Issue Section License Authors who publish with this journal agree to the following terms: Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.