When Solving Dyspareunia Is Not Enough to Restore Sexual Function in Women With Deep Infiltrating Endometriosis Treated With Dienogest

João Paulo Leonardo-Pinto, Cristina Laguna Benetti‐Pinto, Daniela Angerame Yela
Journal of sex & marital therapy · 2018 · vol. 45(1) , pp. 44–49 · doi:10.1080/0092623x.2018.1474411 · PMID:29757096 · W2804573645
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Dienogest treatment for deep infiltrating endometriosis reduced dyspareunia and improved sexual function, but did not fully restore sexual function in affected women.

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Abstract

The aim of the study was to evaluate dyspareunia and sexual function (SF) in women with deep infiltrating endometriosis (DIE) who were treated with dienogest (DNG) for 12 months. The prospective cohort study took place at the University of Campinas, Brazil, and included 30 women with sonographic diagnosis of DIE and sexual dysfunction treated with 2 mg/daily DNG for 12 months. SF parameters were assessed by the Female Sexual Function Index (FSFI) before and after treatment, and dyspareunia was quantified through the visual analog scale (VAS) during the follow-ups performed every three months. Statistical analysis was performed by ANOVA test and through the use of software SAS, Version 9.4. Women were on average 36.13 ± 6.24 years old, and all of them showed sexual dysfunction (FSFI =17.6 ± 5.7) before DNG; 88.3% had dyspareunia as the main symptom related to DIE (VAS before: 5.3 ± 3.1). At the end of the treatment, dyspareunia showed a decrease of intensity (VAS after: 3.7 ± 3.3; p = .0093) and an improvement on FSFI index was accomplished (p = .0023); however, it did not restore SF completely, considering the FSFI cutoff < 26.55. Long-term treatment for DIE with DNG has provided a decrease in dyspareunia and also an enhancement of SF, although SF has not been restored to normal levels.

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Condition tags

mesh:D004414mesh:D004715mesh:D017699endometriosisdie_deep_infiltratingdyspareunia

MeSH descriptors

Dyspareunia Endometriosis Hormone Antagonists Nandrolone Pelvic Pain Sexual Dysfunction, Physiological Adult Brazil Dyspareunia Dyspareunia Endometriosis Endometriosis Female Hormone Antagonists Humans Middle Aged Nandrolone Nandrolone Pelvic Pain Pelvic Pain

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