Use of dienogest in endometriosis: a narrative literature review and expert commentary

Ally Murji; K. Biberoğlu; Kutay Biberoğlu; Jinhua Leng; Michael D Mueller; Thomas Römer; Michele Vignali; M. Vignali; Maria Yarmolinskaya; Maria I. Yarmolinskaya

doi:10.1080/03007995.2020.1744120

Use of dienogest in endometriosis: a narrative literature review and expert commentary

Ally Murji, K. Biberoğlu, Kutay Biberoğlu, Jinhua Leng, Michael D Mueller, Thomas Römer, Michele Vignali, M. Vignali, Maria Yarmolinskaya, Maria I. Yarmolinskaya

Current medical research and opinion · 2020 · vol. 36(5) , pp. 895–907 · doi:10.1080/03007995.2020.1744120 · PMID:32175777 · W3010977327

review OA: bronze CC0 ⤵ 73 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Dienogest is an effective and tolerable treatment for endometriosis, offering advantages over combined hormonal contraceptives, and should be used according to guidelines and individual patient needs.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Overall, the evidence demonstrates that dienogest offers an effective and tolerable alternative or adjunct to surgery and provides many advantages over combined hormonal contraceptives for the treatment of endometriosis. It is important that treatment guidelines are followed and care is tailored to the woman's individual needs and desires.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Nandrolone Bone Density Bone Density Endometriosis Female Hormone Antagonists Hormone Antagonists Humans Nandrolone Nandrolone Nandrolone

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Adenomyosis: a systematic review of medical treatment via openalex
A dose‐ranging study to determine the efficacy and safety of 1, 2, and 4 mg of dienogest daily for endometriosis via openalex
Analysis of psychopathological comorbidity behind the common symptoms and signs of endometriosis via openalex
Clinical experience of long-term use of dienogest after surgery for ovarian endometrioma via openalex
Comparative, open-label prospective study on the quality of life and sexual function of women affected by endometriosis-associated pelvic pain on 2 mg dienogest/30 µg ethinyl estradiol continuous or 21/7 regimen oral contraceptive via openalex
Consensus on current management of endometriosis via openalex
Continuous versus cyclic oral contraceptives after laparoscopic excision of ovarian endometriomas: a systematic review and metaanalysis via openalex
Current and emerging treatment options for endometriosis via openalex
Current understanding on pharmacokinetics, clinical efficacy and safety of progestins for treating pain associated to endometriosis via openalex
Deep Infiltrating Endometriosis Treatment with Dienogest: A Pilot Study via openalex
Définition, description, formes anatomo-cliniques, pathogenèse et histoire naturelle de l’endométriose, RPC Endométriose CNGOF-HAS via openalex
Determinants of long-term clinically detected recurrence rates of deep, ovarian, and pelvic endometriosis via openalex
Diagnosis and management of endometriosis: a systematic review of international and national guidelines via openalex
Dienogest via openalex
Dienogest via openalex
Dienogest and deep infiltrating endometriosis: The remission of symptoms is not related to endometriosis nodule remission via openalex
Dienogest and the breast via openalex
Dienogest, a novel synthetic steroid, overcomes hormone-dependent cancer in a different manner than progestins via openalex
Dienogest, a synthetic steroid, suppresses both embryonic and tumor-cell-induced angiogenesis via openalex
Dienogest compared with gonadotropin‐releasing hormone agonist after conservative surgery for endometriosis via openalex
Dienogest for Treatment of Endometriosis in Chinese Women: A Placebo-Controlled, Randomized, Double-Blind Phase 3 Study via openalex
Dienogest in long-term treatment of endometriosis via openalex
Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study via openalex
Dienogest or Norethindrone acetate for the treatment of ovarian endometriomas: Can we avoid surgery? via openalex
Dienogest therapy during the early stages of recurrence of endometrioma might be an alternative therapeutic option to avoid repeat surgeries via openalex
Differences in characteristics among 1,000 women with endometriosis based on extent of disease via openalex
Effectiveness of Dienogest for Treatment of Recurrent Endometriosis: Multicenter Data via openalex
Effect of dienogest on pain and ovarian endometrioma occurrence after laparoscopic resection of uterosacral ligaments with deep infiltrating endometriosis via openalex
Effects of long-term postoperative dienogest use for treatment of endometriosis on bone mineral density via openalex
Efficacy and safety of dienogest in patients with endometriosis: A single-center observational study over 12 months via openalex
Efficacy and Safety of Long-Term Use of Dienogest in Women With Ovarian Endometrioma via openalex
Endometriosis and the estrogen threshold theory. Relation to surgical and medical treatment. via openalex
Endometriosis: Diagnosis and Management via openalex
Endometriosis: Epidemiology, Diagnosis and Clinical Management via openalex
Endometriosis in Adolescence: Practical Rules for an Earlier Diagnosis via openalex
Endometriosis - Morphology, clinical presentations and molecular pathology via openalex
Epidemiology of endometriosis: a large population‐based database study from a healthcare provider with 2 million members via openalex
Evaluation of the efficacy and safety of dienogest in the treatment of painful symptoms in patients with adenomyosis: a randomized, double-blind, multicenter, placebo-controlled study via openalex
Fatigue – a symptom in endometriosis via openalex
Feelings and expectations in endometriosis: Analysis of open comments from a cohort of endometriosis patients via openalex
Gonadotropin-releasing hormone agonist plus “add-back” hormone replacement therapy for treatment of endometriosis: a prospective, randomized, placebo-controlled, double-blind trial via openalex
High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners via openalex
Hormonal contraception in women with endometriosis: a systematic review via openalex
Hormone treatment of endometriosis: The estrogenthreshold hypothesis via openalex
Long-Term Results of Uterine Artery Embolization for Symptomatic Adenomyosis via openalex
Long-term treatment of endometriosis with dienogest: retrospective analysis of efficacy and safety in clinical practice via openalex
Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial via openalex
<p>Effects of long-term treatment with Dienogest on the quality of life and sexual function of women affected by endometriosis-associated pelvic pain</p> via openalex
Maintenance therapy with dienogest following gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain via openalex
Medical treatment of endometriosis-related pain via openalex
Molecular and Cellular Pathogenesis of Endometriosis via openalex
New trends of progestins treatment of endometriosis via openalex
Oral contraceptives and endometriosis: the past use of oral contraceptives for treating severe primary dysmenorrhea is associated with endometriosis, especially deep infiltrating endometriosis via openalex
Oral contraceptives and risk of endometriosis: a systematic review and meta-analysis via openalex
Ovulation‐Inhibiting Effects of Dienogest in a Randomized, Dose‐Controlled Pharmacodynamic Trial of Healthy Women via openalex
Pathogenetic Mechanisms of Deep Infiltrating Endometriosis via openalex
Patients with adenomyosis are more likely to have deep endometriosis via openalex
Postoperative administration of dienogest for suppressing recurrence of disease and relieving pain in subjects with ovarian endometriomas via openalex
Postoperative administration of dienogest plus estradiol valerate versus levonorgestrel‐releasing intrauterine device for prevention of pain relapse and disease recurrence in endometriosis patients via openalex
Prevalence of adenomyosis in women undergoing surgery for endometriosis via openalex
Prevalence of migraines in adolescents with endometriosis via openalex
Prevention of the recurrence of symptom and lesions after conservative surgery for endometriosis via openalex
Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills via openalex
Recurrence of ovarian endometrioma after laparoscopic excision: Risk factors and prevention via openalex
Reduced pelvic pain in women with endometriosis: efficacy of long-term dienogest treatment via openalex
Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes via openalex
Risk factors of treatment discontinuation due to uterine bleeding in adenomyosis patients treated with dienogest via openalex
Safety of dienogest in the long-term treatment of endometriosis: a one-year, open-label, follow-up study via openalex
Surgical and medical treatment of adenomyosis via openalex
The burden of endometriosis symptoms on health-related quality of life in women in the United States: a cross-sectional study via openalex
The social and psychological impact of endometriosis on women's lives: a critical narrative review via openalex
Time elapsed from onset of symptoms to diagnosis of endometriosis in a cohort study of Brazilian women via openalex
Treatment of pelvic pain associated with endometriosis: a committee opinion via openalex
Use of dienogest over 53 weeks for the treatment of endometriosis via openalex
Uterine artery embolisation for symptomatic adenomyosis—Mid-term results via openalex
When Solving Dyspareunia Is Not Enough to Restore Sexual Function in Women With Deep Infiltrating Endometriosis Treated With Dienogest via openalex
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W1832956514 via openalex
W4234519361 via openalex
W2212973592 via openalex
W4244565353 via openalex
W2171709369 via openalex
W2163315477 via openalex
W2586772905 via openalex
W2139720529 via openalex
W2132577372 via openalex
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W2614075773 via openalex
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W2121659507 via openalex
W2765420687 via openalex
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Cited by (50)

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pubmed: last seen: 2026-05-13T22:22:11.167363+00:00

License: CC0 · commercial use OK

[1] Adenomyosis: a systematic review of medical treatment via openalex

[2] A dose‐ranging study to determine the efficacy and safety of 1, 2, and 4 mg of dienogest daily for endometriosis via openalex

[3] Analysis of psychopathological comorbidity behind the common symptoms and signs of endometriosis via openalex

[4] Clinical experience of long-term use of dienogest after surgery for ovarian endometrioma via openalex

[5] Comparative, open-label prospective study on the quality of life and sexual function of women affected by endometriosis-associated pelvic pain on 2 mg dienogest/30 µg ethinyl estradiol continuous or 21/7 regimen oral contraceptive via openalex

[6] Consensus on current management of endometriosis via openalex

[7] Continuous versus cyclic oral contraceptives after laparoscopic excision of ovarian endometriomas: a systematic review and metaanalysis via openalex

[8] Current and emerging treatment options for endometriosis via openalex

[9] Current understanding on pharmacokinetics, clinical efficacy and safety of progestins for treating pain associated to endometriosis via openalex

[10] Deep Infiltrating Endometriosis Treatment with Dienogest: A Pilot Study via openalex

[11] Définition, description, formes anatomo-cliniques, pathogenèse et histoire naturelle de l’endométriose, RPC Endométriose CNGOF-HAS via openalex

[12] Determinants of long-term clinically detected recurrence rates of deep, ovarian, and pelvic endometriosis via openalex

[13] Diagnosis and management of endometriosis: a systematic review of international and national guidelines via openalex

[14] Dienogest via openalex

[15] Dienogest via openalex

[16] Dienogest and deep infiltrating endometriosis: The remission of symptoms is not related to endometriosis nodule remission via openalex

[17] Dienogest and the breast via openalex

[18] Dienogest, a novel synthetic steroid, overcomes hormone-dependent cancer in a different manner than progestins via openalex

[19] Dienogest, a synthetic steroid, suppresses both embryonic and tumor-cell-induced angiogenesis via openalex

[20] Dienogest compared with gonadotropin‐releasing hormone agonist after conservative surgery for endometriosis via openalex

[21] Dienogest for Treatment of Endometriosis in Chinese Women: A Placebo-Controlled, Randomized, Double-Blind Phase 3 Study via openalex

[22] Dienogest in long-term treatment of endometriosis via openalex

[23] Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study via openalex

[24] Dienogest or Norethindrone acetate for the treatment of ovarian endometriomas: Can we avoid surgery? via openalex

[25] Dienogest therapy during the early stages of recurrence of endometrioma might be an alternative therapeutic option to avoid repeat surgeries via openalex

[26] Differences in characteristics among 1,000 women with endometriosis based on extent of disease via openalex

[27] Effectiveness of Dienogest for Treatment of Recurrent Endometriosis: Multicenter Data via openalex

[28] Effect of dienogest on pain and ovarian endometrioma occurrence after laparoscopic resection of uterosacral ligaments with deep infiltrating endometriosis via openalex

[29] Effects of long-term postoperative dienogest use for treatment of endometriosis on bone mineral density via openalex

[30] Efficacy and safety of dienogest in patients with endometriosis: A single-center observational study over 12 months via openalex

[31] Efficacy and Safety of Long-Term Use of Dienogest in Women With Ovarian Endometrioma via openalex

[32] Endometriosis and the estrogen threshold theory. Relation to surgical and medical treatment. via openalex

[33] Endometriosis: Diagnosis and Management via openalex

[34] Endometriosis: Epidemiology, Diagnosis and Clinical Management via openalex

[35] Endometriosis in Adolescence: Practical Rules for an Earlier Diagnosis via openalex

[36] Endometriosis - Morphology, clinical presentations and molecular pathology via openalex

[37] Epidemiology of endometriosis: a large population‐based database study from a healthcare provider with 2 million members via openalex

[38] Evaluation of the efficacy and safety of dienogest in the treatment of painful symptoms in patients with adenomyosis: a randomized, double-blind, multicenter, placebo-controlled study via openalex

[39] Fatigue – a symptom in endometriosis via openalex

[40] Feelings and expectations in endometriosis: Analysis of open comments from a cohort of endometriosis patients via openalex

[41] Gonadotropin-releasing hormone agonist plus “add-back” hormone replacement therapy for treatment of endometriosis: a prospective, randomized, placebo-controlled, double-blind trial via openalex

[42] High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners via openalex

[43] Hormonal contraception in women with endometriosis: a systematic review via openalex

[44] Hormone treatment of endometriosis: The estrogenthreshold hypothesis via openalex

[45] Long-Term Results of Uterine Artery Embolization for Symptomatic Adenomyosis via openalex

[46] Long-term treatment of endometriosis with dienogest: retrospective analysis of efficacy and safety in clinical practice via openalex

[47] Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial via openalex

[48] <p>Effects of long-term treatment with Dienogest on the quality of life and sexual function of women affected by endometriosis-associated pelvic pain</p> via openalex

[49] Maintenance therapy with dienogest following gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain via openalex

[50] Medical treatment of endometriosis-related pain via openalex

[51] Molecular and Cellular Pathogenesis of Endometriosis via openalex

[52] New trends of progestins treatment of endometriosis via openalex

[53] Oral contraceptives and endometriosis: the past use of oral contraceptives for treating severe primary dysmenorrhea is associated with endometriosis, especially deep infiltrating endometriosis via openalex

[54] Oral contraceptives and risk of endometriosis: a systematic review and meta-analysis via openalex

[55] Ovulation‐Inhibiting Effects of Dienogest in a Randomized, Dose‐Controlled Pharmacodynamic Trial of Healthy Women via openalex

[56] Pathogenetic Mechanisms of Deep Infiltrating Endometriosis via openalex

[57] Patients with adenomyosis are more likely to have deep endometriosis via openalex

[58] Postoperative administration of dienogest for suppressing recurrence of disease and relieving pain in subjects with ovarian endometriomas via openalex

[59] Postoperative administration of dienogest plus estradiol valerate versus levonorgestrel‐releasing intrauterine device for prevention of pain relapse and disease recurrence in endometriosis patients via openalex

[60] Prevalence of adenomyosis in women undergoing surgery for endometriosis via openalex

[61] Prevalence of migraines in adolescents with endometriosis via openalex

[62] Prevention of the recurrence of symptom and lesions after conservative surgery for endometriosis via openalex

[63] Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills via openalex

[64] Recurrence of ovarian endometrioma after laparoscopic excision: Risk factors and prevention via openalex

[65] Reduced pelvic pain in women with endometriosis: efficacy of long-term dienogest treatment via openalex

[66] Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes via openalex

[67] Risk factors of treatment discontinuation due to uterine bleeding in adenomyosis patients treated with dienogest via openalex

[68] Safety of dienogest in the long-term treatment of endometriosis: a one-year, open-label, follow-up study via openalex

[69] Surgical and medical treatment of adenomyosis via openalex

[70] The burden of endometriosis symptoms on health-related quality of life in women in the United States: a cross-sectional study via openalex

[71] The social and psychological impact of endometriosis on women's lives: a critical narrative review via openalex

[72] Time elapsed from onset of symptoms to diagnosis of endometriosis in a cohort study of Brazilian women via openalex

[73] Treatment of pelvic pain associated with endometriosis: a committee opinion via openalex

[74] Use of dienogest over 53 weeks for the treatment of endometriosis via openalex

[75] Uterine artery embolisation for symptomatic adenomyosis—Mid-term results via openalex

[76] When Solving Dyspareunia Is Not Enough to Restore Sexual Function in Women With Deep Infiltrating Endometriosis Treated With Dienogest via openalex

[77] W2802526932 via openalex

[78] W2065386825 via openalex

[79] W2058876585 via openalex

[80] W2045458073 via openalex

[81] W2026012728 via openalex

[82] W2008635153 via openalex

[83] W2890404096 via openalex

[84] W2896694652 via openalex

[85] W2899183806 via openalex

[86] W1832956514 via openalex

[87] W4234519361 via openalex

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[89] W4244565353 via openalex

[90] W2171709369 via openalex

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[93] W2139720529 via openalex

[94] W2132577372 via openalex

[95] W2123876576 via openalex

[96] W2614075773 via openalex

[97] W2615713587 via openalex

[98] W2121659507 via openalex

[99] W2765420687 via openalex

[100] W2116834271 via openalex