Dienogest and the breast

Adolf E Schindler, Alexandria Henkel, Bernd Christensen, Michel Oettel, Claudia Moore
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2009 · vol. 25(7) , pp. 472–474 · doi:10.1080/09513590902836536 · PMID:19499407 · W2135449787
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⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

A pilot study found that treating endometriosis with high-dose dienogest for 24 weeks significantly reduced breast size and mastopathic changes in women.

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Abstract

In a clinical pilot study, 21 women with endometriosis have been primarely treated with dienogest 2 x 10 mg daily p.o. for 24 weeks. Besides the effect on endometriosis the action of such high-dose progestogen treatment on the breast was evaluated by breast ultrasound prior to medication and at 24 weeks of medical treatment. In all women, a significant size reduction of the mammary gland (p < 0.023) and regression of mastopathic changes were observed. There was a non-significant reduction (p = 0.089) of the maximum diameter of the ducts. The portion of the fatty tissue increased slightly, but not significantly (p = 0.348).

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Condition tags

endometriosis

MeSH descriptors

Breast Endometriosis Fibrocystic Breast Disease Hormone Antagonists Nandrolone Adult Breast Endometriosis Female Fibrocystic Breast Disease Fibrocystic Breast Disease Hormone Antagonists Humans Nandrolone Nandrolone Pilot Projects Ultrasonography, Mammary Young Adult

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