Use of dienogest in endometriosis: a narrative literature review and expert commentary

Murji A, Ally Murji, Kutay Biberoğlu, K. Biberoğlu, Biberoğlu K, Leng J, Jinhua Leng, Michael D. Mueller, Mueller MD, Thomas Römer, Römer T, M. Vignali, Michele Vignali, Maria Yarmolinskaya, Maria I. Yarmolinskaya
Current medical research and opinion · 2020 · vol. 36(5) , pp. 895–907 · doi:10.1080/03007995.2020.1744120 · PMID:32175777 · W3010977327
Review OA: bronze CC0 ⤵ 73 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Dienogest is an effective and tolerable treatment for endometriosis, offering advantages over combined hormonal contraceptives, and should be used according to guidelines and individual patient needs.

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Abstract

Objective: Endometriosis affects up to 10% of women of reproductive age, and the main goal of treatment is to relieve symptoms. Progestins have been the mainstay of endometriosis suppression, of which dienogest has become an important option in many parts of the world. This is an expert literature review, with recommendations on the use of dienogest in the context of various clinical considerations when treating endometriosis.Methods: A search of PubMed was conducted for papers published between 2007 and 2019 on the use of dienogest in endometriosis. Experts reviewed these and included those they considered most relevant in clinical practice, according to their own clinical experience.Results: Evidence regarding the long-term use (>15 months) of dienogest for the management of endometriosis is presented, with experts concluding that the efficacy of dienogest should be assessed primarily on its impact on pain and quality of life. Fertility preservation, the option to avoid or delay surgery, and managing bleeding irregularities that can occur with this treatment are also considered. Counseling women on potential bleeding risks before starting treatment may be helpful, and evidence suggests that few women discontinue treatment for this reason, with the benefits of treatment outweighing any impact of bleeding irregularities.Conclusions: Overall, the evidence demonstrates that dienogest offers an effective and tolerable alternative or adjunct to surgery and provides many advantages over combined hormonal contraceptives for the treatment of endometriosis. It is important that treatment guidelines are followed and care is tailored to the woman's individual needs and desires.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Nandrolone Bone Density Bone Density Bone Density Endometriosis Endometriosis Female Female Hormone Antagonists Hormone Antagonists Hormone Antagonists Humans Humans Nandrolone Nandrolone Nandrolone Nandrolone

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (50)

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europepmc
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openalex
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License: CC0 · commercial use OK