The use of combined oral contraceptives in patients with endometriosis

И. В. Кузнецова
In: Medical alphabet · 2023 · pp. 14–20 · doi:10.33667/2078-5631-2023-3-14-20 · W4362555495
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This review discusses hormonal therapy for endometriosis, focusing on combined oral contraceptives (COCs) and other approved treatments that suppress ovulation and target endometriotic implants based on the disease's estrogen-dependent and progesterone-resistant pathogenesis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This narrative review discusses the use of combined oral contraceptives (КОК) as part of hormonal therapy for endometriosis, framing treatment within endocrine pathogenesis involving estrogen dependence and progesterone resistance, alongside downstream effects on apoptosis, oxidative stress, inflammation, and neuroangiogenesis. The review outlines the rationale for suppressing ovulation via inhibition of the hypothalamus–pituitary–ovary axis and describes that certain hormonal agents, including КОК, are officially approved to relieve endometriosis symptoms. A major caveat is that, as a review, it does not provide new patient-level results or quantify comparative efficacy of КОК using a single systematic methodology. This paper is centrally about endometriosis — it specifically reviews combined oral contraceptives in the hormonal management of endometriosis.

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Abstract

Endometriosis is a benign inflammatory hormone-dependent disease characterized by pain and infertility. It seriously affect women’s health., endometriosis is a chronic disease it requires long-term treatment. Currently, hormonal drugs are most widely used for the treatment of endometriosis, which is based on the endocrine mechanisms of its pathogenesis. Key points are estrogen dependence and progesterone resistance, which provide implantation of ectopic endometrial cells, reduce apoptosis and increase oxidative stress, inflammation and neuroangiogenesis. the pain and infertility is explained by hormonal and inflammatory changes, as well as the systemic diseases and psychiatric disorders often associated with endometriosis. Hormonal treatment of endometriosis is aimed at suppressing ovulation through inhibition of the hypothalamic-pituitary-ovarian axis, as well as directly on endometrioid implants. Gonadotropin-releasing hormone (GnRH) agonists and antagonists, progestins, combined oral contraceptives (COCs) are now offcially approved for use to relieve the symptoms of endometriosis. The review provides information on the current possibilities of hormonal therapy for endometriosis, based on an understanding of the pathogenesis of the disease.

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Condition tags

endometriosisinfertility

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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last seen: 2026-06-10T17:14:06.276822+00:00
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