Statins: Is it New Weaponry against Endometriosis?

Sharmin Salam, Farzana Deeba, Jesmin Banu, Shakeela Ishrat, Chandana Saha, Susmita Sinha, Pratiksha Patel, Mainul Haque
In: Advances in Human Biology · 2025 · vol. 15(2) , pp. 267–277 · doi:10.4103/aihb.aihb_25_25 · W4407829651
article OA: diamond CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study evaluated dienogest plus atorvastatin versus dienogest alone for symptomatic endometrioma, finding both regimens reduced endometrioma size and pain.

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Abstract

Introduction: Endometriosis is a prevalent female illness linked to infertility and pelvic pain. In vitro studies suggest that statins reduce endometrial stroma growth and hinder angiogenesis. The objectives of this study were to assess if dienogest (DNZ) + atorvastatin (ATV) is more effective than DNZ alone in women with symptomatic endometrioma. Materials and Methods: This prospective comparative study was done in the Department of Reproductive Endocrinology and Infertility, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh. Women with symptomatic endometrioma were enrolled in the study and were divided into the treatment arm of ATV plus DNZ and the control arm of DNZ alone. To examine the association between Group A (DNZ plus Statin) and Group B (DNZ) regarding the statistical model, a multilevel mixed-effects regression analysis was conducted to evaluate the relationship between the primary exposures, additional independent factors and outcomes such as endometrioma size and pain level. Results: Participants of Group A experienced infertility for more than 3 years than Group B, which was found statistically significant ( P < 0.001). Again, a mixed-level regression analysis was conducted to assess the association between the primary exposure showed that post-intervention, endometrioma size decreased by 0.81 units (95% confidence interval [CI]: −1.10, −0.52, P < 0.001) and pain levels decreased by 3.81 units (95% CI: −4.31, −3.30, P < 0.001). Interestingly, pain levels were 1.64 units higher in the obese group (95% CI: 0.36, 2.92, P = 0.012). Amongst the participants reporting menstrual problems, endometrioma size was reduced by 0.92 units (95% CI: −1.32, −0.52, P < 0.001). Conclusion: The findings revealed that both treatment regimens efficiently lowered the size of endometriomas and relieved discomfort in the study subjects.

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Outcome instruments

VAS-pain MUSA

Condition tags

endometriosisendometriomainfertility

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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