Effectiveness of Dienogest for Treatment of Recurrent Endometriosis: Multicenter Data

Jae Hoon Lee, Jae Yen Song, Kyong Wook Yi, Sa Ra Lee, Dong-Yun Lee, Dong‐Yun Lee, Jung‐Ho Shin, Jung-Ho Shin, SiHyun Cho, Seok Kyo Seo, Sung Hoon Kim, Sung Kim
Reproductive sciences (Thousand Oaks, Calif.) · 2018 · vol. 25(10) , pp. 1515–1522 · doi:10.1177/1933719118779733 · PMID:29848190 · W2806443010
article OA: green CC0 ⤵ 30 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This study evaluated dienogest effectiveness in 121 women with recurrent endometriosis, finding significant reductions in pain, endometrioma size, and CA-125 levels with common side effects like irregular bleeding.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The paper evaluated the effectiveness and safety of dienogest (2 mg daily) in 121 women clinically diagnosed with recurrent endometriosis, treated for more than 24 weeks using multicenter data. Changes in endometriosis-associated pain measured by VAS, serum CA-125 levels, and recurrent endometrioma size were tracked, with findings that VAS pain scores significantly decreased from baseline to 24 weeks and that endometrioma size and CA-125 levels also significantly declined compared with baseline (with CA-125 reductions persisting to 72 weeks). Irregular bleeding was the most common adverse event, reported in about 30% of participants, and 42% overall experienced adverse events. This paper is centrally about endometriosis — it specifically assesses dienogest effectiveness for recurrent endometriosis across multiple centers.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Hormone Antagonists Nandrolone Adult Amenorrhea Amenorrhea CA-125 Antigen CA-125 Antigen Endometriosis Endometriosis Endometriosis Female Hormone Antagonists Humans Multicenter Studies as Topic Nandrolone Nandrolone Pain Pain Pain Measurement

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (44)

Cited by (30)

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