Novel Strategies to Fight Endometriosis

Maria Rosa Maduro
Reproductive sciences (Thousand Oaks, Calif.) · 2018 · vol. 25(9) , pp. 1305–1306 · doi:10.1177/1933719118795947 · PMID:30126347 · W2888268239
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⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-06-14 ⓘ

This review discusses novel therapeutic strategies for endometriosis, including modulating stem cell trafficking, targeting microRNAs, addressing oxidative stress, and utilizing environmental manipulations.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

This brief article (“Novel Strategies to Fight Endometriosis”) is a perspective-style piece that surveys emerging strategies for endometriosis, referencing prior work on pathogenesis, therapeutic options, stem cell trafficking, oxidative stress and epigenetic modification, environmental manipulations, specific drug effectiveness (e.g., dienogest for recurrent disease), and molecular biomarkers such as microRNA profiles and UGT1A1 expression in lesions. It synthesizes the referenced literature rather than presenting new experimental or clinical results. The main limitation is that, as a summary article, it does not provide original data or a systematic methodology for evaluating the evidence it cites. This paper is centrally about endometriosis — it focuses specifically on summarizing novel approaches and evidence aimed at fighting endometriosis.

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References Vercellini P, Viganò P, Somigliana E, Fedele L. Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol. 2014;10(5):261–75. GBD 2015 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016 8;388(10053):1545–1602. Rogers PA, Adamson GD, Al-Jefout M, Becker CM, D’Hooghe TM, Dunselman GA, Fazleabas A, Giudice LC, Horne AW, Hull ML, Hummelshoj L, Missmer SA, Montgomery GW, Stratton P, Taylor RN, Rombauts L, Saunders PT, Vincent K, Zondervan KT; WES/WERF Consortium for Research Priorities in Endometriosis. Research Priorities for Endometriosis. Reprod Sci. 2017;24(2):202–226. Ersoy GS, Zolbin MM, Cosar E, Mamillapalli R, Taylor HS Medical Therapies for Endometriosis Differentially Inhibit Stem Cell Recruitment. Reprod Sci. 2017 Jun;24(6):818–823. Pluchino N, Taylor HS. Endometriosis and Stem Cell Trafficking. Reprod Sci. 2016;23(12):1616–1619. Wang L, Huang W, Ren C, Zhao M, Jiang X, Fang X, Xia X. Analysis of Serum microRNA Profile by Solexa Sequencing in Women With Endometriosis. Reprod Sci. 2016;23(10):1359–70. Seifer BJ, Su D, Taylor HS. Circulating miRNAs in Murine Experimental Endometriosis. Reprod Sci. 2017;24(3):376–381. Ito F, Yamada Y, Shigemitsu A, Akinishi M, Kaniwa H, Miyake R, Yamanaka S, Kobayashi H. Role of Oxidative Stress in Epigenetic Modification in Endometriosis. Reprod Sci. 2017;24(11):1493–1502. Torres-Reverón A, Rivera LL, Flores I, Appleyard CB. Environmental Manipulations as an Effective Alternative Treatment to Reduce Endometriosis Progression. Reprod Sci. 2017 Jan 1: 1933719117741374. Lee JH, Song JY, Yi KW, Lee SR, Lee DY, Shin JH, Cho S, Seo SK, Kim SH. Effectiveness of Dienogest for Treatment of Recurrent Endometriosis: Multicenter Data. Reprod Sci. 2018 Jan 1: 1933719118779733. Piccinato CA, Neme RM, Torres N, da Silva Victor E, Brudniewski HF, Rosa E Silva JC, Ferriani RA. Enhanced UGT1A1 Gene and Protein Expression in Endometriotic Lesions. Reprod Sci. 2018 Jan 1:1933719118764255. Rights and permissions About this article Cite this article Maduro, M.R. Novel Strategies to Fight Endometriosis. Reprod. Sci. 25, 1305–1306 (2018). https://doi.org/10.1177/1933719118795947 Published: Version of record: Issue date: DOI: https://doi.org/10.1177/1933719118795947

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Animals Animals Endometriosis Endometriosis Female Female Humans Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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