Enhanced UGT1A1 Gene and Protein Expression in Endometriotic Lesions

Carla A Piccinato, Carla de Azevedo Piccinato, Rosa M Neme, Rosa Maria Neme, Natália Torres, Elivane da Silva Victor, H.F. Brudniewski, Heloísa F Brudniewski, Júlio C. Rosa e Silva, Rui A Ferriani, Rui Alberto Ferriani
Reproductive sciences (Thousand Oaks, Calif.) · 2018 · vol. 25(9) , pp. 1371–1375 · doi:10.1177/1933719118764255 · PMID:29540112 · W2789955450
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

UGT1A1 gene and protein expression was increased in endometriotic lesions compared to endometria, particularly in deep-infiltrating lesions.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This study examined gene and protein expression of the estrogen-glucuronidating enzyme UGT1A1 in eutopic endometrium from non-affected women and endometriosis-affected women, as well as in endometriotic lesions, focusing on differences related to lesion depth. UGT1A1 mRNA was detected at similar frequencies across lesion and eutopic samples, but transcript levels were higher in deep-infiltrating lesions and also in non-deep-infiltrating lesions compared with control endometrium and eutopic endometrium from women with endometriosis. Protein expression of UGT1A1 was significantly more frequent in endometriotic lesions than in endometria, and protein levels were higher in deep-infiltrating than in non-deep-infiltrating lesions. The paper does not explicitly state a limitation in the provided text, but it only reports expression differences and does not directly measure estrogen net availability or functional enzyme activity. This paper is centrally about endometriosis — it focuses on enhanced UGT1A1 gene and protein expression in endometriotic lesions and how that may relate to local estrogen metabolism.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Glucuronosyltransferase Adult Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Glucuronosyltransferase Glucuronosyltransferase Humans RNA, Messenger RNA, Messenger RNA, Messenger UGT1A1 Enzyme

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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