Effect of dienogest on pain and ovarian endometrioma occurrence after laparoscopic resection of uterosacral ligaments with deep infiltrating endometriosis

Akiyoshi Yamanaka, Yamanaka A, Tomonori Hada, Matsumoto T, Tsuyoshi Matsumoto, Kanno K, Kiyoshi Kanno, Akira Shirane, A Shirane, Shirane A, Shiori Yanai, Yanai S, Nakajima S, S. Nakajima, Saori Nakajima, Ebisawa K, K. Ebisawa, Keiko Ebisawa, Yoshiaki Ota, Ota Y, M. Andou, Andou M, Masaaki Andou
European journal of obstetrics, gynecology, and reproductive biology · 2017 · vol. 216 , pp. 51–55 · doi:10.1016/j.ejogrb.2017.07.014 · PMID:28728071 · W2735845128
article OA: closed CC0 ⤵ 23 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study investigated the impact of dienogest on pain and endometrioma recurrence following laparoscopic uterosacral ligament resection for deep infiltrating endometriosis.

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Abstract

ObjectiveTo evaluate the effect of dienogest (DNG) in preventing the occurrence of pain and endometriomas after laparoscopic resection of uterosacral ligaments (USLs) with deep infiltrating endometriosis (DIE).Study designThis retrospective analysis included 126 patients who underwent laparoscopic resection of USLs with DIE followed by postoperative administration of DNG or no medication. Every 6 months postoperatively, patients answered questions and underwent ultrasound examination to identify pain and/or endometrioma.ResultThere were three (5.0%) cases of endometrioma in 59 patients from the DNG group and 21 (31.3%) cases in 67 patients from the no medication group (P=0.0002). Pain returned to preoperative levels in eight (11.9%) cases in the no medication group. No recurrence of pain occurred in the DNG group (P=0.0061).ConclusionThe administration of DNG after resection of USLs with DIE significantly reduces the occurrence rate of endometriosis-related pain and endometriomas.

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Condition tags

endometriosisdie_deep_infiltratingendometrioma

MeSH descriptors

Endometriosis Hormone Antagonists Nandrolone Ovarian Diseases Pain Peritoneal Diseases Endometriosis Endometriosis Female Hormone Antagonists Humans Laparoscopy Nandrolone Nandrolone Ovarian Diseases Ovarian Diseases Pain Peritoneal Diseases Peritoneal Diseases Recurrence

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