Application of Dienogest In the Treatment of Endometriosis

Yuguang Chen, Ge Yang, Yining Zhao
In: Highlights in Science, Engineering and Technology · 2022 · vol. 8 , pp. 69–73 · doi:10.54097/hset.v8i.1112 · W4293001010
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Abstract

Endometriosis is a condition that exists endometrioid epithelium and/or endometrialmatrix muscular layer,usually accompanied by inflammatory processes.The new progesterone,Dienogest (DNG),has no estrogen,anti-estrogen and androgen activities,at the same time,DNGhas anti androgen activity.With a favorable safety and tolerability profile,DNG could relief pain and reduce ovarian endometriosis cysts,reduces the recurrence,meanwhile,DNG also has good effect on recurrent endometriosis.DNG mainly mediates the hypothalamus,pituitary and ovarian axis to inhibit the functions of ovarian.It can also inhibit the synthesis of estrogen metabolic enzymes,to reduce estrogen level.Through anti-inflammation and anti-angiogenesis,DNG could inhibit the development of pain,inhibite the occurrence and development of EMT lesions,which can be used as medicine for long-term management of endometriosis.Side effects such as uterine bleeding was observed,inform the patient in advance of compliance,careful long-term follow-up is required.

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endometriosis

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