Efficacy of Dienogest for Prevention of Endometriosis Recurrence: A Systematic Review and Meta-Analysis

Hussain MA Assiri, Mashail AS Alomari, Atheer DM Alshehri, Asma SY Alahmari, Manal M Alasmari
In: World Family Medicine Journal /Middle East Journal of Family Medicine · 2022 · vol. 20(11) · doi:10.5742/mewfm.2022.95251391 · W4307756746
review OA: closed CC0
Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Postoperative dienogest treatment significantly reduces endometriosis recurrence rates, improves pain, and lowers side effects compared to control groups.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This paper is a systematic review and meta-analysis evaluating the efficacy of dienogest for preventing endometriosis recurrence, synthesizing evidence from published studies. The authors pooled outcomes across included trials to estimate dienogest’s effect on recurrence prevention. A key limitation is that, as with many systematic reviews, the reliability of the pooled estimate depends on the quality, design heterogeneity, and completeness of the underlying studies. This paper is centrally about endometriosis — specifically, dienogest’s efficacy for preventing endometriosis recurrence.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Aim of Study: To evaluate the efficacy of postoperative dienogest for prevention of endometriosis recurrence. Methods: Several databases were used to search for recent studies (i.e., published in 2016-2020). The search keywords included: “dienogest,” and “endometr*,” Patients who were not treated with dienogest were considered controls. Reviews, comments, animal trials, case reports, abstracts, single-arm studies, low-quality studies, and non-English articles were excluded. The primary outcome of interest was to determine the odds of recurrence in patients who received dienogest compared to controls who were managed expectantly, or offered a substitute hormonal therapy. Secondary outcomes included pain improvement and side effects of received treatment. Results: Included studies comprised three retrospective cohort studies, and two prospective cohort studies. These studies included 608 patients; 216 were managed in the Dienogest Group, while 392 were managed in the Control Group (163 received hormonal suppression, and 228 received no treatment). Overall, the recurrence rate of endometriosis in patients receiving Dienogest was 8/216, i.e., 3.7 events per 100 treated women over a mean duration of 28.5 months, and 1.3 recurrences per 1000 woman-months. On the other hand, the recurrence rate of endometriosis in the Control Group was 69/392 recurrences over a mean duration of 29.3 months, i.e., 17.6 per 100 women (6.0 recurrences per 1000 women-months). Difference in recurrence rates between study groups was statisticallysignificant (X2=24.3, p<0.001). Reported recurrence rates were significantly less among patients in the Dienogest Group than those in the Control Group, with a pooled estimate of RR = 0.239, and 95% CI: 0.119-0.488. Generally, patients in the Dienogest Group experienced less pain and less side effects than those in the control group. Conclusions: Endometriosis patients who receive dienogest following conservative surgery have a significantly lower rate of recurrence, better pain control, and less side effects than their control counterparts. Key Words: Endometriosis, Dienogest, Goserelin, Systematic Review, Meta-Analysis,
Full text 8,278 characters · extracted from oa-doi-fallback · click to expand
| Editorial Abdulrazak Abyad Original Contribution Awareness and attitude toward antidepressants in the population of Riyadh, Saudi Arabia [Abstract] [pdf] Yasir Ibrahim Alsenaidi, Omar Dawas AlDawas, Abdullah Ahmad AlFihaid, Mohammed Sultan AlZimami, Rayan Faleh AlQahtani, Khalid A. Bin Abdulrahman DOI: 10.5742/MEWFM.2022.95251360 Predictive factors of postoperative paralytic ileus following abdominal surgery: a clinical study [Abstract] [pdf] Tamer M. Abdelrahman, Ahmed K. Alharthi, Salem S. Alamri, Amer M. Alnefaie, Baraa A. Omar, Mohammed A. Alzahrani DOI: 10.5742/MEWFM.2022.95251361 Burden, clinical aspects and correlates of dyspepsia among the population in Jeddah, Saudi Arabia [Abstract] [pdf] Fathi El-Gamal, Lujain Baajajah, Ghufran Katib, Shaima aljohani, Ghada aljuhani, Huda Zahra DOI: 10.5742/MEWFM.2022.95251362 Medical students' understanding and interpreting abilities for Complete Blood Counts (CBC) in clinical practice [Abstract] [pdf] Tahir Jameel, Mukhtiar Baig, Mohammed Ibrahim Mohammed Albejad, Taha Mohammed Abdullah Aljifri, Bander Abdualziz Taher Almaghrabi, Raneem Youseef Qashqaui DOI: 10.5742/MEWFM.2022.95251363 Post-catheterization complications in diabetic patients with myocardial infarction [Abstract] [pdf] Ali Mohammed Alamri, Mohammed Dafer Alahmari, Amar Abdullah A. Al Qahtani, Amjad Abdulrahman H. Al Qahtani, Sabah Mubarak H. Alshahrani, Lujain Saleh A. Alamri, Walaa Muteb D Alahmari, Amnah Saad H Alharthi, Manar Abdullah S Alqahtani DOI: 10.5742/MEWFM.2022.95251374 Assessment of Quality of Life among Elderly Patients Attending Primary Healthcare Centers in Aseer Region, Saudi Arabia [Abstract] [pdf] Osama Mohammed Alqahtani, Awad Saeed Alsamghan, Safar Abadi Alsaleem, Alaa Ali Saeed Alyahya, Faizah Salem Alrazhi, Asma Sulaiman Alshahrani, Atheer Saeed M Alasmary, Asma Abdullah Saeed, Ranyah Ahmed Nasser Gwadi, Bushra Mohammed Alotayfi, Nadine Thabet Saeed Alshahrani DOI: 10.5742/MEWFM.2022.95251375 Factors affecting patients' waiting time at the Radiology Department [Abstract] [pdf] Waleed Abdullah Ali Omar, Reham Mohammed Al-Shahrani, Mohammed Ahmed Almushafi, Hussein M. Boraie DOI: 10.5742/MEWFM.2022.95251376 Elastography as predictor for thyroid nodule malignancy [Abstract] [pdf] Reyad Alsuqair, Nermeen Omar, Sultanah Alshreef, Yazeed Alharthi, Mohammad Algarni, Abdulaziz Aljuaid, Omar J. AlThaqufi DOI: 10.5742/MEWFM.2022.95251378 Population and Community Studies Knowledge, Attitude and Perceptions of the population towards Vitamin D in Jeddah, Saudi Arabia [Abstract] [pdf] Fathi El-Gamal, Ahmed Daghmash, Amjad Yapah, Ahmed Buraymah, Farah AL Tahawi, Fatima Khairurllah DOI: 10.5742/MEWFM.2022.95251364 The Prevalence of Constipation and Its Associated Complications in Aseer Region by Using Wexner Scale [Abstract] [pdf] Muneer Jan Bhat, Sultan Mohammed Abdullah Alkorbi, Nejad Mubasher Mohammed Almaem, Abdullah Omar Musleh Alqarni, Shadi Ahmad Abdullah Alamri, Lama Gasem Asiri, Khalid Ali Abdullah Alsaiary DOI: 10.5742/MEWFM.2022.95251365 Association Between Blood Donation and Improved Sleep Quality Among Blood Donors in Aseer Region [Abstract] [pdf] Mohammed Abdulrahman Alshibli, Zayed Mofareh Ahmed Asiri, Ghanem Ahmed Mohammed Al Ghanem, Musaad Abdulrahman M Al Shibli, Naif Mohammed Alotaibi, Saeed Abdullah Saeed Alasmari, Abdullah Safar Saeed Al safar, Bader Saad S Alshahrani, Nada Hamzah Albarqi, Naif Sultan S Alqahtani, Abdulrhman Abdullah Ali Mansour DOI: 10.5742/MEWFM.2022.95251366 Parental awareness of pediatric foreign body aspiration in Taif city, Saudi Arabia [Abstract] [pdf] Badr S. Alam, Mohammed Althomali, Amjad Jawhari, Khalid Faraj, Abdulaziz Alghuraibi, Abdulrahman Alsubaie, Sattam Aljuaid DOI: 10.5742/MEWFM.2022.95251367 Assessment of level of knowledge about cryptorchidism and its complications among paternity age population in the western region of Saudi-Arabia. Cross-sectional Questionnaire based study [Abstract] [pdf] Faisal M. Alfadli, Abdulaziz S. Aljuaid, Muhanad A. Althbaiti, Abdulrahman D. Alhamyani, Ahmed S. Alsoaimi, Khalid M. Alzahrani DOI: 10.5742/MEWFM.2022.95251368 Knowledge, attitudes, and practices of self-ear cleaning among the general population in Riyadh, Saudi Arabia [Abstract] [pdf] Khalid A. Bin Abdulrahman, Faisal A. Alhazani, Faisal T. Alayed, Abdulrahman A. Alomar, Abdulmajeed H. AlSarrani, Abdulaziz M. Albalawi, Firas O Alhussini DOI: 10.5742/MEWFM.2022.95251370 Assessment of patients' knowledge and attitudes towards self-insulin administration and skin manifestations in the regions of Aseer [Abstract] [pdf] Rawan Shawabkeh, Muteb Aldajam, Halimah Alshehri, Mohammed Muqri, Mohammed Mukharrib, Mahdi Alzamanan, Mona Alhamad, Sukayna Alhamad, Haya Alnumayr, Muidh Aldajam, Hisham Alqahtani DOI: 10.5742/MEWFM.2022.95251387 Regional Covid The Knowledge and Attitude of Precautionary Measurements for COVID-19 Pandemic Among College Students: A Cross-Sectional Study in Jeddah City, Saudi Arabia [Abstract] [pdf] Anas S. Alyazidi, Mahmoud A. Gaddoury, Hussain A. Alkhalifah, Fahad A. Alotibi, Hani A. Turkstani, Abdulaziz T. Jambi, Waheeb S. Aggad DOI: 10.5742/MEWFM.2022.95251371 Education and Training Experience of undergraduate medical students of Al-Imam Mohammad ibn Saud Islamic University (IMSIU) about the international summer elective program (ISEP) [Abstract] [pdf] Khalid Bin Abdulrahman, Alswayed, Khalid E., Alomar, Naif A., Al Thaqfan, Naif A. Abozaid, Hesham S DOI: 10.5742/MEWFM.2022.95251373 Efficacy of Dienogest for Prevention of Endometriosis Recurrence: A Systematic Review and Meta-Analysis [Abstract] [pdf] Hussain MA Assiri, Mashail AS Alomari, Atheer DM Alshehri, Asma SY Alahmari, Manal M Alasmari DOI: 10.5742/MEWFM.2022.95251391 Empathy level among Saudi medical students using the Toronto empathy scale [Abstract] [pdf] Khalid A. Bin Abdulrahman, Majed A. Alsharidah, Badr A. Alobaida, Yazeed N. Alabbadi, Faisal I. Almohsen, Tamim A. Abahussain, Faisal S. Alahmari DOI: 10.5742/MEWFM.2022.95251392 Reviews Vascular dementia - A Narrative Review [Abstract] [pdf] Nasir Alzbeidi, Hamed Alsinawi, Hem Phaterphaker DOI: 10.5742/MEWFM.2022.95251395 Role of MR in Evaluating Multiple Sclerosis [Abstract] [pdf] Rahaf Saad Mohammed Al Jallal, Marwah Saad Mohammed Al Jallal DOI: 10.5742/MEWFM.2022.95251397 Retrospective study Radiological screening for DDH among risky infants in Abha Maternity & Children Hospital from 2019-2021 [Abstract] [pdf] Mahdi M. Alqarni, Khadijah Abdullah Alghanmy, Abdulrhman Ali Hassan, Abdulrahim Ali Hassan, Abduaelah Ali Hassan DOI: 10.5742/MEWFM.2022.95251398 .................................................................................. Middle East Quality Improvement Program (MEQUIP QI&CPD) Chief Editor - Abdulrazak Abyad MD, MPH, MBA, AGSF, AFCHSE ......................................................... Editorial Office - Abyad Medical Center & Middle East Longevity Institute Azmi Street, Abdo Center, PO BOX 618 Tripoli, Lebanon Phone: (961) 6-443684 Fax: (961) 6-443685 Email: [email protected] ......................................................... Publisher - Lesley Pocock medi+WORLD International AUSTRALIA Email: [email protected] ......................................................... Editorial Enquiries - [email protected] ......................................................... Advertising Enquiries - [email protected] ......................................................... While all efforts have been made to ensure the accuracy of the information in this journal, opinions expressed are those of the authors and do not necessarily reflect the views of The Publishers, Editor or the Editorial Board. The publishers, Editor and Editorial Board cannot be held responsible for errors or any consequences arising from the use of information contained in this journal; or the views and opinions expressed. Publication of any advertisements does not constitute any endorsement by the Publishers and Editors of the product advertised. The contents of this journal are copyright. Apart from any fair dealing for purposes of private study, research, criticism or review, as permitted under the Australian Copyright Act, no part of this program may be reproduced without the permission of the publisher. |

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK