Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis

Mariko Miyashita, Miyashita M, Mariko Miyashita‐Ishiwata, Kaori Koga, Takamura M, Masashi Takamura, Gentaro Izumi, Izumi G, Nagai M, Miwako Nagai, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Fujii T, Tomoyuki Fujii, Osuga Y, Yutaka Osuga
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2014 · vol. 30(9) , pp. 644–648 · doi:10.3109/09513590.2014.911279 · PMID:24805834 · W2142777290
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Dienogest treatment of endometriosis patients resulted in reduced proliferation, aromatase expression, and angiogenesis, along with increased apoptosis in endometrioma tissues.

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Abstract

Dienogest is a novel progestin that is highly selective for progesterone receptors and inhibits endometriosis. However, it remains unknown how the administration of dienogest to patients with endometriosis impacts on their lesion tissues. The aim of this study was to evaluate the in vivo effect of dienogest on endometriosis tissue. We collected endometrioma tissues from patients treated with dienogest (N = 7) or not treated (N = 11, controls). Cell proliferation, aromatase expression and blood vessel density were evaluated by staining for Ki67, aromatase and the von Willebrand factor, respectively. Apoptosis was detected using the TUNEL assay. The proportion of Ki67 and aromatase positive epithelial cells was significantly lower in the dienogest group than in controls (p < 0.05, respectively). The number of TUNEL positive cells was significantly higher in the dienogest group (p < 0.05). The density of blood vessels in endometrioma was marginally lower in the dienogest group compared with controls (p = 0.20). Our study demonstrates that endometrioma taken from patients treated with dienogest show remarkable histological features such as reduction of proliferation, aromatase expression and angiogenesis, and increase of apoptosis. This study clarified the impact of dienogest on local histological events that explain its therapeutic effect on endometriosis.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Antineoplastic Agents, Hormonal Aromatase Endometriosis Nandrolone Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal Apoptosis Apoptosis Aromatase Case-Control Studies Cell Proliferation Cell Proliferation Endometriosis Endometriosis Female Humans In Situ Nick-End Labeling Ki-67 Antigen Ki-67 Antigen Nandrolone

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