Dienogest (Monopräparat)
Dienogest monotherapy is a well-documented treatment for endometriosis, though its superiority over other gestagens for pain relief remains unproven.
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The paper reviews dienogest as a single-agent (Monopräparat) treatment option for endometriosis, focusing on its pharmacology and proposed mechanisms for reducing endometriosis-associated pain. It describes dienogest as a 19-nortestosterone derivative with antiandrogenic properties and suggests that pain relief may involve reduced cell proliferation, decreased aromatase expression, and reduced angiogenesis. A key caveat stated is that it has not been shown that dienogest improves endometriosis-related pain significantly more than other gestagens. This paper is centrally about endometriosis — it focuses specifically on dienogest as a well-documented hormonal therapy for endometriosis pain and compares the evidence to other gestagens.
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References (7)
- Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study via openalex
- Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis via openalex
- Efficacy of dienogest vs combined oral contraceptive on pain associated with endometriosis: Randomized clinical trial via openalex
- Impact of Long-Term Dienogest Therapy on Quality of Life in Asian Women with Endometriosis: the Prospective Non-Interventional Study ENVISIOeN via openalex
- Reduced pelvic pain in women with endometriosis: efficacy of long-term dienogest treatment via openalex
- Rethinking mechanisms, diagnosis and management of endometriosis via openalex
- W2101417341 via openalex
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00