Mariko Miyashita‐Ishiwata

ORCID: 0000-0001-8586-7073 · 14 papers in corpus · active 2014-2021

Study types

  • article 12
  • review 2

Condition tags

  • endometriosis 10
  • endometrioma 3
  • adenomyosis 3
  • infertility 1
article 2021
Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation
·doi:10.1016/j.phrs.2021.105856
review 2021
Vascular biology of uterine fibroids: connecting fibroids and vascular disorders
·doi:10.1530/rep-21-0087

Fibroids are benign tumors caused by the proliferation of myometrial smooth muscle cells in the uterus that can lead to symptoms such as abdominal pain, constipation, urinary retention, and infertility. While traditionally thought of as a d…

article 2020
The effects of tokishakuyakusan, a traditional Japanese medicine (kampo), ferulic acid and paeoniflorin, on human endometriotic stromal cells and peritoneal macrophages
Journal of reproductive immunology ·doi:10.1016/j.jri.2020.103104
article 2020
Use of selective PGE2 receptor antagonists on human endometriotic stromal cells and peritoneal macrophages
Molecular human reproduction ·doi:10.1093/molehr/gaaa077

Non-hormonal therapeutic strategies for endometriosis are needed. The aim of this study was to characterize the effects of prostaglandin (PG)E2 receptor inhibitors to explore their potential as novel therapeutic strategies for endometriosis…

review 2020
Uterine Stem Cells and Benign Gynecological Disorders: Role in Pathobiology and Therapeutic Implications
Stem cell reviews and reports ·doi:10.1007/s12015-020-10075-w
article 2019
Endometriosis Triggers Excessive Activation of Primordial Follicles via PI3K-PTEN-Akt-Foxo3 Pathway
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2019-00281

CONTEXT: The ovarian reserve is reduced in patients with endometriosis. We hypothesize that the phosphatidylinositol 3-kinase (PI3K)-phosphatase and tensin homolog deleted on chromosome 10 (PTEN) Akt-Forkhead box O (Foxo3) pathway is involv…

article 2018
Expression of Nerve Injury-Induced Protein1 (Ninj1) in Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719118806395
article 2016
Dienogest reduces nerve growth factor expression in human adenomyosis
·doi:10.1016/j.jri.2016.04.184
article 2016
Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2016.10.053
article 2016
Drospirenone reduces inflammatory cytokines, vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) expression in human endometriotic stromal cells
Journal of reproductive immunology ·doi:10.1016/j.jri.2016.12.002
article 2016
Effects of 1,25-Dihydroxy Vitamin D3 on Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2016-1515

CONTEXT: Endometriosis is an estrogen-dependent, chronic inflammatory disease. Recent studies have shown that vitamin D (VD) is an effective modulator of the immune system and plays an important role in controlling many inflammatory disease…

article 2016
Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12489

PROBLEM: Resistance to apoptosis, together with inflammatory and invasive activity, contributes to the pathogenesis of endometriosis; therefore, approaches that can safely enhance apoptosis in endometriotic tissue are highly sought after as…

article 2015
Drospirenone induces decidualization in human eutopic endometrial stromal cells and reduces DNA synthesis of human endometriotic stromal cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.03.023
article 2014
Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology ·doi:10.3109/09513590.2014.911279

Dienogest is a novel progestin that is highly selective for progesterone receptors and inhibits endometriosis. However, it remains unknown how the administration of dienogest to patients with endometriosis impacts on their lesion tissues. T…