Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells

Ayumi Taguchi, Kaori Koga, Kei Kawana, Tomoko Makabe, Fusako Sue, Mariko Miyashita, Mariko Miyashita‐Ishiwata, Mitsuyo Yoshida, Yoko Urata, Gentaro Izumi, Masashi Tkamura, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Osamu Wada‐Hiraike, Osamu Wada-Hiraike, Tomoyuki Fujii, Yutaka Osuga
American journal of reproductive immunology (New York, N.Y. : 1989) · 2016 · vol. 75(4) , pp. 486–492 · doi:10.1111/aji.12489 · PMID:26782781 · W2293723117
article OA: closed CC0 ⤵ 36 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Resveratrol was found to suppress survivin expression and enhance TRAIL-induced apoptosis in human endometriotic stromal cells.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

PROBLEM: Resistance to apoptosis, together with inflammatory and invasive activity, contributes to the pathogenesis of endometriosis; therefore, approaches that can safely enhance apoptosis in endometriotic tissue are highly sought after as a means of managing the disease. Although resveratrol (RVT) is known to induce apoptosis or increase sensitivity to apoptotic stimuli in various cancer cell types, its effect on human endometriosis has remained uncertain. This study aimed to investigate whether RVT induces or enhances apoptosis in human endometriotic stromal cells (ESCs). METHOD OF STUDY: Endometriotic tissues were collected, during laparoscopies, from women affected by ovarian endometriosis. ESCs were prepared, cultured, and treated with RVT. Apoptosis was assessed by annexin V-PI staining. Survivin mRNA expression in ESCs was examined using RT-PCR. ESCs were pre-treated with or without RVT and then incubated with TNF-α-related-apoptosis-inducing ligand (TRAIL), which is a known pro-apoptotic molecule. RESULTS: RVT alone did not induce apoptosis in ESCs. RVT significantly reduced survivin mRNA expression (P < 0.05). Pre-treatment with RVT significantly enhanced TRAIL-induced apoptosis (8.13 ± 0.83% (control) versus 29.19 ± 7.39% (pre-treated with RVT), P < 0.05). CONCLUSION: This study indicates that RVT suppresses survivin expression and enhances TRAIL-induced apoptosis in ESCs.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Apoptosis Endometriosis Endometrium Stilbenes Apoptosis Apoptosis Cells, Cultured Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans Inhibitor of Apoptosis Proteins Inhibitor of Apoptosis Proteins Resveratrol Stilbenes Stromal Cells Stromal Cells

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (43)

Cited by (36)

Source provenance

europepmc
last seen: 2026-06-18T06:15:08.409253+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:21:19.813018+00:00
License: CC0 · commercial use OK