Regression of Endometrial Implants by Resveratrol in an Experimentally Induced Endometriosis Model in Rats

Ahmet Mete ErgenoÄŸlu, Ahmet Mete Ergenoğlu, Ahmet Ãzgür Yeniel, Ahmet Özgür Yeniel, Oytun Erbaş, Oytun ErbaÅŸ, Hà ⁄ seyin AktuÄŸ, Hüseyin Aktuğ, Nuri Yildirim, Nuri Yıldırım, Murat UlukuÅŸ, Murat Ulukuş, Dilek Taşkıran, Dilek Taskiran
Reproductive sciences (Thousand Oaks, Calif.) · 2013 · vol. 20(10) , pp. 1230–1236 · doi:10.1177/1933719113483014 · PMID:23536571 · W2042153379
article OA: closed CC0 ⤵ 47 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

Resveratrol treatment significantly reduced endometriotic implant size and inflammatory markers like VEGF and MCP-1 in a rat model.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This study evaluated whether resveratrol could regress surgically induced endometriotic implants in rats by administering 10 mg/kg/day for a treatment period and assessing inflammatory markers plus histopathology at the end. Rats were randomized to saline controls (n=6) or resveratrol (n=6), and the authors measured changes in implant size and angiogenic/inflammatory mediators including VEGF and MCP-1 in both peritoneal fluid and plasma, along with VEGF expression in endometriotic tissue. Resveratrol significantly reduced implant size, decreased VEGF levels and MCP-1 levels, and suppressed VEGF expression in the implants, accompanied by considerable histological changes in treated foci. The paper’s main caveat is that only one dose and a small sample size were tested, with the authors calling for future studies using different doses to broaden the findings. This paper is centrally about endometriosis — resveratrol-mediated regression of experimentally induced endometrial implants in a rat endometriosis model via antiangiogenic and anti-inflammatory effects.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Disease Models, Animal Endometriosis Endometriosis Endometrium Stilbenes Animals Endometriosis Endometrium Endometrium Female Random Allocation Rats Rats, Sprague-Dawley Remission Induction Remission Induction Resveratrol Stilbenes Stilbenes

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