Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells

Aydin Arici, Arici A, A Arici, Engin Oral, E Oral, Oral E, E Attar, Erkut Attar, Attar E, Salli I. Tazuke, S I Tazuke, Tazuke SI, D L Olive, Olive DL, David L. Olive
Fertility and Sterility · 1997 · vol. 67(6) , pp. 1065–1072 · doi:10.1016/s0015-0282(97)81440-9 · PMID:9176445 · W2091673490
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This study investigated monocyte chemotactic protein-1 (MCP-1) levels in peritoneal fluid of women with endometriosis and its effect on mesothelial cell expression.

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Abstract

ObjectiveTo investigate monocyte chemotactic protein-1 concentrations in the peritoneal fluid (PF) of women with or without endometriosis, then assess peritoneal mesothelial cells as a potential source of monocyte chemotactic protein-1.DesignProspective study.SettingUniversity medical center.Patient(s)Women with (n = 60) or without (n = 18) endometriosis.Intervention(s)First monocyte chemotactic protein-1 levels in PF were measured, then mesothelial cells in culture were treated with cytokines.Main outcome measure(s)In PF and culture supernatants, monocyte chemotactic protein-1 was measured by ELISA. In vitro monocyte chemotactic protein-1 messenger RNA expression was evaluated by Northern analysis.Result(s)The median concentration of monocyte chemotactic protein-1 in PF of control women was 137 pg/mL (conversion factor to SI unit, 0.115; range, 12 to 418 pg/mL); that of women with moderate endometriosis was 205 pg/mL (range 65 to 6,000 pg/mL); and that of those with severe endometriosis was 1,165 pg/mL (0 to 2,602 pg/mL). Within the moderate to severe endometriosis group, monocyte chemotactic protein-1 levels were higher in women with untreated endometriosis (354 pg/mL range 0 to 6,000 pg/mL) than in women receiving GnRH agonist (128 pg/mL, range 0 to 216 pg/mL). In the control group, monocyte chemotactic protein-1 levels were higher in the proliferative phase than in the secretory phase. Mesothelial cells produced constitutively monocyte chemotactic protein-1; moreover, both interleukin-1 alpha and tumor necrosis factor-alpha induced higher levels of monocyte chemotactic protein-1.Conclusion(s)Levels of monocyte chemotactic protein-1 in PF were higher during the proliferative phase than secretory phase of control women and increased in moderate to severe endometriosis. The regulated expression of monocyte chemotactic protein-1 may recruit macrophages into PF and contribute to the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Chemokine CCL2 Endometriosis Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal Ascitic Fluid Ascitic Fluid Cells, Cultured Chemokine CCL2 Chemokine CCL2 Endometriosis Endometriosis Endometriosis Epithelial Cells Epithelium Epithelium Epithelium Female Humans Interleukin-1

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