Peritoneal fluid concentrations of β-chemokines in endometriosis

Margari KM, Kalliopi-Maria Margari, Alexandros Zafiropoulos, Eleftheria Hatzidaki, Giannakopoulou C, Christina Giannakopoulou, Arici A, Aydın Arıcı, Aydin Arici, Ioannis Matalliotakis, Matalliotakis I
European journal of obstetrics, gynecology, and reproductive biology · 2013 · vol. 169(1) , pp. 103–107 · doi:10.1016/j.ejogrb.2013.02.010 · PMID:23474119 · W2000467027
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This study measured peritoneal fluid β-chemokines and found significantly lower MCP-1 levels in endometriosis patients, particularly in earlier stages, compared to controls.

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Abstract

OBJECTIVE: To examine whether the levels of MCP-1, RANTES and MCP-3 in the peritoneal fluid correlate with endometriosis. STUDY DESIGN: Patients with endometriosis were compared with controls. SETTING: Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA. SUBJECTS: This study involved 95 women of reproductive age who were undergoing laparoscopy for evaluation of infertility or for pelvic pain. They were divided into an endometriosis group (n=54) and a control group (n=41). INTERVENTIONS: Peritoneal fluid samples were obtained and β-chemokines (MCP-1, RANTES and MCP-3) were measured using ELISA. STATISTICAL ANALYSIS: Mean and median values were used to present values. Due to the non-normality of chemokines, a log transformation was applied. Differences were examined using independent samples t-test. One-way ANOVA and Tukey HSD multiple comparison post hoc tests were applied. A significance level at 0.05 was set. RESULTS: The levels of MCP-1 are higher (p for log values=0.024) in the control group (mean=687.6, SD=467.7 pg/ml) than those of the endometriosis group (mean=570.4, SD=633.1 pg/ml). The same is true for the median values of MCP-1 (control median=568.5, endometriosis median=384.7 pg/ml). MCP-3 and RANTES do not differ significantly (MCP-3 p=0.787, RANTES p=0.153). The levels of MCP-1 in patients with stage II endometriosis are significantly lower in comparison with stage III (p=0.048) and stage IV (p=0.033) endometriosis. CONCLUSIONS: A decrease in the concentrations of MCP-1 in stage I endometriosis has been observed, which is even larger in stage II, in contrast to stage III and stage IV endometriosis, which exhibit concentrations similar to the controls.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Chemokine CCL2 Chemokine CCL5 Chemokine CCL7 Endometriosis Ascitic Fluid Ascitic Fluid Chemokine CCL2 Chemokine CCL2 Chemokine CCL5 Chemokine CCL5 Chemokine CCL7 Chemokine CCL7 Endometriosis Endometriosis Female Female Humans Humans

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