The role of monocyte chemotactic protein-1 in intraperitoneal adhesion formation

H B Zeyneloglu, Hulusi Bülent Zeyneloğlu, L M Senturk, Levent M. Şentürk, Seli E, Emre Seli, E Seli, E Oral, Ebru Oral, Oral E, David L. Olive, Olive DL, D L Olive, Aydın Arıcı, Arici A, A Arici
Human Reproduction · 1998 · vol. 13(5) , pp. 1194–1199 · doi:10.1093/humrep/13.5.1194 · PMID:9647546 · W1985335819
article OA: closed CC0 ⤵ 15 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Women with intraperitoneal adhesions had elevated peritoneal fluid MCP-1 levels, but this correlation was not observed in patients with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Abdomino-pelvic adhesions arise from infection, endometriosis, or peritoneal injury during surgery, and represent a significant source of morbidity in women of reproductive age. Monocyte chemotactic protein-1 (MCP-1) plays a role in the chemotaxis of mononuclear cells and fibroblasts in a murine wound repair model. To evaluate the role of MCP-1 in intraperitoneal adhesion formation, we investigated peritoneal fluid MCP-1 levels of women undergoing laparoscopy. Patients without endometriosis were divided into two groups: normal fertile women undergoing bilateral tubal ligation without intraperitoneal adhesions (n=14) and women with pelvic adhesions (n=8). Patients with endometriosis were arranged into two groups: women with (n=17) and without (n=17) adhesions. Peritoneal fluid MCP-1 levels were quantified using an enzyme-linked immunosorbent assay (ELISA). Peritoneal biopsy samples were immunostained for the detection of MCP-1 protein and macrophages, and were also processed for the presence of MCP-1 mRNA expression. Among women without endometriosis, the median peritoneal fluid MCP-1 level was 144 pg/ml (range 54-261) in women without adhesions and was 336 pg/ml (range 130-2494) in women with adhesions (P=0.01). There was a significant correlation between adhesion scores and MCP-1 levels (r=0.50; P=0.018). Among women with endometriosis, peritoneal fluid MCP-1 levels significantly correlated with the stage of the disease. The presence or absence of adhesions did not significantly affect the peritoneal fluid MCP-1 levels in this group of women. In summary, we have found that women with adhesions have elevated peritoneal fluid MCP-1 levels. However, we were not able to show an incremental effect of adhesions on peritoneal fluid MCP-1 levels of patients with endometriosis. Thus, we conclude that factors besides the intraperitoneal adhesions contribute to the elevated peritoneal fluid MCP-1 levels in patients with endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Chemokine CCL2 Peritoneal Diseases Adult Animals Ascitic Fluid Ascitic Fluid Base Sequence Case-Control Studies Chemokine CCL2 Chemokine CCL2 Chemotaxis, Leukocyte Chemotaxis, Leukocyte Endometriosis Endometriosis Endometriosis Endometriosis Female Humans Immunohistochemistry Mice

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

Cited by (14)

Source provenance

europepmc
last seen: 2026-10-03T06:16:46.921020+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:10:40.754221+00:00
unpaywall
last seen: 2026-10-03T06:31:36.481334+00:00
License: CC0 · commercial use OK