Peritoneal adhesions in human and veterinary medicine: from pathogenesis to therapy. A review

Annalisa Rizzo, Massimo Spedicato, M. Mutinati, Giuseppe Minoia, Stefano Angioni, Felicita Jirillo, Maria A. Pantaleo, Raffaele Luigi Sciorsci
In: Immunopharmacology and Immunotoxicology · 2010 · vol. 32(3) , pp. 481–494 · doi:10.3109/08923970903524367 · PMID:20128633 · W2154841599
review OA: closed CC0 ⤵ 5 in-corpus citations
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This review examines the pathogenesis and therapeutic strategies for peritoneal adhesions, connective tissues that form between abdominal organs and can cause infertility and intestinal obstruction in humans and animals.

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Abstract

Any peritoneal inflammatory process consequent to infections or surgical injuries may induce abdominal adhesion formation. Peritoneal adhesions are connective laciniae that develop among abdomino-pelvic organs that limit physiologic visceral motion. Consequently, fertility may be impaired, and intestinal obstruction and pelvic pain may develop, mainly in subjects that had undergone gynaecological surgery. This review illustrates the pathogenic steps of adhesiogenesis and the therapeutic scenario that evolved over the years to tackle the threat of peritoneal adhesions, both in domestic animals and in women.

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