Decreased levels of the potent regulator of monocyte/macrophage activation, interleukin-13, in the peritoneal fluid of patients with endometriosis
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Women with endometriosis showed significantly lower levels of the macrophage-inhibiting cytokine interleukin-13 in their peritoneal fluid compared to control subjects.
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Abstract
Endometriosis is characterized by an increase in the number, activation and secretory activity of peritoneal fluid macrophages. Factors regulating the activation of these cells may be important in the pathophysiology of this disease. In this study we measured by enzyme-linked immunosorbent assay the concentrations of the macrophage inhibitory factor interleukin (IL)-13 in the peritoneal fluid of women with and without endometriosis. It was found that women with endometriosis had significantly lower amounts of IL-13 (95 +/- 9.8 pg/ml) in peritoneal fluid, compared with women without endometriosis (115 +/- 30 pg/ml) (P < 0.01). No cycle-specific variation was evident for either group. Another macrophage inhibitory interleukin (IL-10) was also measured, but no differences between women with (16.1 +/- 13.2 pg/ml) or without (10.3 +/- 5.6 pg/ml) endometriosis were seen. The immunolocalization of IL-13 was assessed in eutopic and ectopic endometrium and in isolated peritoneal fluid cells. Glandular epithelial cells and stromal cells in both eutopic and ectopic endometrium were immunopositive for IL-13. No cycle-specific differences in the immunolocalization of IL-13 were seen. In conclusion, the reduced amounts of IL-13 in the peritoneal fluid of women with endometriosis may lead to a lack of suppression of macrophage activation, thereby contributing to the overall pathogenesis of this disease.
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Cited by (50)
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- The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights 2019
- Interleukin in endometriosis-associated infertility-pelvic pain: systematic review and meta-analysis 2019
- Fas-Related Apoptosis of Peritoneal Fluid Macrophages in Endometriosis Patients: Understanding the Disease 2017
- Biomarkers for Endometriosis in Saliva, Urine, and Peritoneal Fluid 2017
- Potential Etiologies of Unexplained Infertility in Females 2015
- Development of peritoneal endometriosis: Characterisation of immune environment in peritoneal endometriotic lesions 2015
- The Endometrium in Adenomyosis 2015
- Inflammation and Cytokines in Endometriosis 2014
- A Novel Mouse Model of Endometriosis Mimics Human Phenotype and Reveals Insights into the Inflammatory Contribution of Shed Endometrium 2014
- Structural and molecular features of the endomyometrium in endometriosis and adenomyosis 2013
- Endometriosis 2013
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- Theories on the Pathogenesis of Endometriosis 2011
- Interleukin-6 and other soluble factors in peritoneal fluid and endometriomas and their relation to pain and aromatase expression 2010
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- Endometriose und Inflammation 2007
- Polymorphisms in Exons 1B and 1C of the Type I Interleukin‐1 Receptor Gene in Patients with Endometriosis 2006
- Is Endometriosis Associated with Systemic Subclinical Inflammation? 2006
- Interleukin-10 gene promoter polymorphisms and their protein production in peritoneal fluid in patients with endometriosis 2006
- Different concentrations of interleukins in the peritoneal fluid of women with endometriosis: relationships with lymphocyte subsets 2004
- Concentrations of Neopterin and Interleukin-10 in Peritoneal Fluid and in Serum of Women with Endometriosis 2004
- Peritoneal fluid environment in endometriosis. Clinicopathological implications. 2003
- Coordinated but depressed expression of human leukocyte antigen-DR, intercellular adhesion molecule-1, and CD14 on peritoneal macrophages in women with pelvic endometriosis 2003
- The Role of Cytokines in Endometriosis* 2003
- Peritoneal fluid environment in endometriosis 2003
- Serum and Peritoneal Markers for Endometriosis 2003
- Endometriosis is associated with alterations in the relative abundance of proteins and IL-10 in the peritoneal fluid 2003
- Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial 2002
- Uterine Chemokines in Reproductive Physiology and Pathology 2002
- Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial 2002
- New considerations for the pathogenesis of endometriosis 2002
- Pathogenesis of Endometriosis 2002
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- Role of cytokines in endometriosis 2001
- Theories of endometriosis 2001
- Role of cytokines in endometriosis 2001
- Is endometriosis an endometrial disease? 2000
- 10.1016/s1047-9422(03)00073-7 2000
- Effect of Pelvic Endometrial Implants on Overall Reproductive Functions of Female Rats 1999
- Pathophysiology of Endometriosis-Associated Infertility 1999
- Pathogenesis of Endometriosis: The Role of Peritoneal Fluid 1999
- Chemokines and human reproduction 1999
- Current Concepts in the Pathogenesis of Endometriosis 1999
- The effect of lignocaine on sperm phagocytosis in the peritoneal fluid from women with or without endometriosis 1998
- Peritoneal fluid concentrations of interleukin-8 in women with endometriosis: relationship to stage of disease 1998
- Endometriosis: abnormal endometrium and dysfunctional immune response 1998
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