Potential Etiologies of Unexplained Infertility in Females

Daniela Galliano, António Pellicer
In: Unexplained Infertility · 2015 · pp. 141–147 · doi:10.1007/978-1-4939-2140-9_13 · W1177949594
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This chapter discusses potential female factors underlying unexplained infertility, including ovarian and tuboperitoneal issues, fertilization failure, endometrial receptivity, and embryonic factors.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This chapter reviews unexplained infertility, defined as the inability of couples to achieve pregnancy after 12 months of unprotected intercourse without an identified cause, and outlines potential female etiologies including ovarian dysfunction/abnormal folliculogenesis, tuboperitoneal factors, fertilization failure, impaired endometrial receptivity, and embryonic factors. It also emphasizes that UI should be viewed as relative subfertility rather than a fixed condition, noting that treatment-independent live-birth rates are estimated at 40–60% over 3 years, with female age and duration of infertility as key prognostic factors. A major limitation is that even after “the most accurate diagnostic workup,” many couples still lack an explanation, reflecting the chapter’s narrative synthesis rather than presenting new primary data. Relevance to endometriosis: the chapter explicitly cites endometriosis and committee guidance on “endometriosis and infertility” as part of the broader infertility differential and discussion of related mechanisms, though its main focus is the etiologic framework for unexplained infertility.

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