The results of in vitro fertilization-embryo transfer in couples with unexplained infertility failing to conceive with superovulation and intrauterine insemination

Timur Gürgan; Bülent Urman; Hakan Yaralı́; Hüsnü A. Kişnişçi

doi:10.1016/s0015-0282(16)57661-4

The results of in vitro fertilization-embryo transfer in couples with unexplained infertility failing to conceive with superovulation and intrauterine insemination

Timur Gürgan, Bülent Urman, Hakan Yaralı́, Hüsnü A. Kişnişçi

In: Fertility and Sterility · 1995 · vol. 64(1) , pp. 93–97 · doi:10.1016/s0015-0282(16)57661-4 · PMID:7789586 · W2406441027

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This study investigated the outcomes of in vitro fertilization-embryo transfer in couples with unexplained infertility who had previously failed to achieve pregnancy with superovulation and intrauterine insemination.

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Abstract

ObjectiveTo determine the results of IVF-ET in couples with long-standing unexplained infertility who had failed to conceive with four to six cycles of superovulation and IUI.DesignRetrospective case control series.SettingUniversity IVF-ET center.PatientsOne hundred seventeen couples with unexplained infertility who had failed to conceive with superovulation and IUI underwent 157 cycles of IVF-ET. Results were compared with 194 tubal factor couples subjected to 250 IVF-ET cycles within the same time period.ResultsTotal fertilization failure events were more common (20.4% versus 7.6%) and tended to be repetitive in couples with unexplained infertility. When total fertilization failure events were excluded, fertilization rates (57.8% versus 60.9%) and cumulative clinical pregnancy rates over three cycles (55.4% versus 46.5%) were similar in unexplained infertility and tubal disease groups.ConclusionsCouples with unexplained infertility failing to conceive with superovulation and IUI have a favorable outcome when treated subsequently with IVF-ET. Conception rates similar to couples with tubal disease may be expected despite a higher incidence of total fertilization failure events.